The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
LOCALIZATION OF THE PRIMARY METABOLIC BLOCK PRODUCED BY 2-DEOXYGLUCOSE
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“2-DG is phosphorylated by hexokinase to produce 2-deoxyglucose-6-phosphate, which cannot be further metabolized by cells. It therefore accumulates intracellularly and competitively inhibits hexokinase to slow glucose uptake (Figure 3).”
From Targeting Metabolism for Cancer Therapy (2017) · cites this paper as Wick et al., 1957
Citations
Cites
The Determination of Enzyme Dissociation Constants
Lineweaver, H., & Burk, D. (1934) · Journal of the American Chemical Society · doi:10.1021/ja01318a036 · Cited by 12,031
A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETECTION AND DETERMINATION OF KETO SUGARS AND TRIOSES
Dische, Z., & Borenfreund, E. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77782-5 · Cited by 1,108
SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE
Sols, A., & Crane, R. K. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65384-0 · Cited by 599
The effect of 2-desoxy-D-glucose on glycolysis and respiration of tumor and normal tissues.
Woodward, G. E., & Hudson, M. T. (1954) · PubMed · Cited by 158
2-Desoxy-D-glucose as an antagonist of glucose in yeast fermentation
Cramer, F. B., & Woodward, G. E. (1952) · Journal of the Franklin Institute · doi:10.1016/0016-0032(52)90852-1 · Cited by 123
SUGAR UTILIZATION IN EVISCERATED RABBITS
Drury, D. R. (1935) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1935.111.2.289 · Cited by 107
Self-citationThe Action of Ammonia on Allophanic Azide
LIPSCHITZ, W. L. (1944) · Journal of the American Chemical Society · doi:10.1021/ja01232a510 · Cited by 54
2-Deoxyglucose--A Metabolic Block for Glucose.
Wick, A. N., Drury, D. R., & Morita, T. N. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-89-21881 · Cited by 41
Self-citationBergmann, M. F., Schotte, H., & Lechinsky, W. (1922) · Berichte der deutschen chemischen Gesellschaft (A and B Series) · doi:10.1002/cber.19220550122 · Cited by 41
The effect of 6-deoxy-6-fluoro-d-glucose on yeast fermentation and on hexokinase
Blakley, E. R., & Boyer, P. D. (1955) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(55)90281-x · Cited by 32
Selective fermentation and phosphorylation of sugars by sauternes yeast
Sols, A. (1956) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(56)90263-3 · Cited by 30
THE EFFECT OF 2-DEOXYGLUCOSE ON THE METABOLISM OF GLUCOSE, FRUCTOSE, AND GALACTOSE BY RAT DIAPHRAGM
Nakada, H. I., & Wick, A. N. (1956) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)89925-6 · Cited by 28
Self-citationGalactose Metabolism by the Isolated Rat Diaphragm
Nakada, H. I., & Wick, A. N. (1956) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1956.185.1.23 · Cited by 7
Self-citation
Research works printed but not linked: 4
- Woodward, 1954, Cancer Res., 14, 599
- Cramer, 1952, J. Franklin Inst., 253, 277, 10.1016/0016-0032(52)90852-1 · DOI
- Woodward, 1956, J. Franklin Inst., 259, 643
- Levine, 1954, Recent Progress Hormone Res., 9, 343
Cited by
Sorted by citations
Sokoloff, L., Reivich, M., Kennedy, C., Rosiers, M. H. D., Patlak, C. S., Pettigrew, K. D., Sakurada, O., & Shinohara, M. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10649.x · Cited by 6,000
Targeting Metabolism for Cancer Therapy
Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.08.028 · Cited by 971
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
Kalender, A., Selvaraj, A., Kim, S. Y., Gulati, P., Brûlé, S., Viollet, B., Kemp, B. E., Bardeesy, N., Dennis, P., Schlager, J. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.014 · Cited by 889
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 736
Metadata
- Authors
- Wick, A. N., Drury, D. R., Nakada, H. I., Wolfe, J. B., Britton, B., & Grabowski, R.
- Affiliations
- Scripps Clinic (US)
- ORCID
- Wick, Arne N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1957-02
- Volume
- 224
- Issue
- 2
- Pages
- 963-969
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1536070820
- Cited by
- 780
- References
- 13
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 14 · 2023: 24 · 2022: 27 · 2021: 27 · 2020: 33 · 2019: 37 · 2018: 30 · 2017: 18 · 2016: 24 · 2015: 24 · 2014: 13 · 2013: 8 · 2012: 10
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- 2-deoxyglucose, metabolic block, glycolysis inhibition, glucose metabolism, enzyme localization, glycolytic enzymes
- MeSH terms
- Deoxyglucose, Glucose, Humans
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