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Structure of the human apolipoprotein B gene.
Open accessAbstract
Human apolipoprotein B100 cDNA is 14 kilobases in length and encodes a 4563-amino acid precursor protein. The corresponding human gene has been isolated as a series of overlapping lambda clones and extends over 43 kilobases. The gene comprises 29 exons and 28 introns. The distribution of introns is extremely asymmetrical, most of them appearing in the 5'-terminal one-third of the gene. Although most of the exons fall within the normal size limits for mammalian genes, two are unusually long: 1906 and 7572 base pairs. The latter exon is by far the longest reported for a vertebrate gene.
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Cited by
Innerarity, T., Mahley, R., Weisgraber, K., Bersot, T., Krauss, R., Vega, G., Grundy, S., Friedl, W., Davignon, J., & McCarthy, B. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42605-7 · Cited by 352
Contois, J. H., McConnell, J. P., Sethi, A. A., Csako, G., Devaraj, S., Hoefner, D. M., & Warnick, G. R. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.118356 · Cited by 326
Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes.
Sparks, J. D., & Sparks, C. E. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38966-5 · Cited by 253
Apolipoproteins: metabolic role and clinical biochemistry applications
Dominiczak, M. H., & Caslake, M. J. (2011) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/acb.2011.011111 · Cited by 238
Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism
Hooper, A. J., van Bockxmeer, F. M., & Burnett, J. R. (2005) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500295113 · Cited by 89
Metadata
- Authors
- Blackhart, B. D., Ludwig, E. M., Pierotti, V. R., Caiati, L., Onasch, M. A., Wallis, S. C., Powell, L., Pease, R., Knott, T. J., & Chu, M. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 261
- Issue
- 33
- Pages
- 15364-15367
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2145167060
- Cited by
- 236
- References
- 0
- FWCI
- 27.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Blackhart, B. D., Ludwig, E. M., Pierotti, V. R., Caiati, L., Onasch, M. A., Wallis, S. C., Powell, L., Pease, R., Knott, T. J., & Chu, M. L. (1986). Structure of the human apolipoprotein B gene. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)66718-3
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