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Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles.
Open accessAbstract
MA104 cells, as well as several other rapidly dividing tissue culture cells, have a folate-binding protein associated with their cell surface. The protein has the properties of a membrane receptor: (a) 5-methyl[3H]tetrahydrofolic acid binds with high affinity (Kd approximately equal to 3 nM); (b) the protein is an integral membrane protein; (c) it appears to deliver physiological concentrations of 5-methyl[3H]tetrahydrofolic acid to the inside of the cell; (d) binding activity is regulated by the concentration of folate within the cell. To better understand the mechanism of action of this receptor, we have studied the pathway of folate internalization. We present evidence that during internalization: (a) folate binds to the membrane receptor; (b) the ligand-receptor complex moves into the cell; (c) the ligand is released from the receptor in an acidic intracellular compartment and moves into the cytoplasm; and (d) the unoccupied receptor returns to the cell surface.
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Cited by
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Metadata
- Authors
- Kamen, B. A., Wang, M. T., Streckfuss, A. J., Peryea, X., & Anderson, R. G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-09
- Volume
- 263
- Issue
- 27
- Pages
- 13602-13609
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1557687412
- Cited by
- 287
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. https://app.cochat.ai/papers/10.1016/s0021-9258(18)68284-5
- The paper
- Kamen, B. A., Wang, M. T., Streckfuss, A. J., Peryea, X., & Anderson, R. G. (1988). Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68284-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
