The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells.
Open accessAbstract
Transforming growth factor beta 1 (TGF-beta 1) regulates the growth, differentiation, or function of nearly all cell types. We now report that TGF-beta 1 increases steady-state levels of its own message in six different normal and transformed cells in culture. Accumulation of TGF-beta 1 mRNA can be detected by Northern blot analysis within 3 h of addition of the peptide to cells, and enhanced message levels persist as long as TGF-beta 1 is present in the culture medium. This autoinduction is half-maximal at approximately 10 PM TGF-beta 1, and maximal stimulation corresponds to a 2-3-fold increase in transcript levels. In normal rat kidney cells, the rise in TGF-beta 1 mRNA is actinomycin D-sensitive and is accompanied by a parallel (approximately 3-fold) increase in secretion of TGF-beta 1 protein in the culture medium of treated cells, as detected by immunoprecipitation of biosynthetically labeled 35S-labeled TGF-beta 1 using specific anti-TGF-beta 1 antibodies. Treatment of normal rat kidney cells with either epidermal growth factor or platelet-derived growth factor also results in an increase in TGF-beta 1 mRNA (2-3-fold), although epidermal growth factor and TGF-beta 1 appear to act via distinct mechanisms since their combined effects are greater than additive.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cell adhesion protein receptors as targets for transforming growth factor-$beta; action
IGNOTZ, R. (1987) · Cell · doi:10.1016/0092-8674(87)90146-2 · Cited by 485
Cited by
TGF-β Signaling in Tumor Suppression and Cancer Progression
Derynck, R., Akhurst, R. J., & Balmain, A. (2001) · Nature Genetics · doi:10.1038/ng1001-117 · Cited by 2,275
Munger, J. S., Huang, X., Kawakatsu, H., Griffiths, M. J. D., Dalton, S. L., Wu, J., Pittet, J.-F., Kaminski, N., Garat, C., Matthay, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80545-0 · Cited by 2,076
Epidermal differentiation: the bare essentials.
Fuchs, E. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.6.2807 · Cited by 658
Amento, E. P., Ehsani, N., Palmer, H., & Libby, P. (1991) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.11.5.1223 · Cited by 609
Platelet-derived growth factor: mechanism of action and possible in vivo function.
Heldin, C. H., & Westermark, B. (1990) · Cell Regulation · doi:10.1091/mbc.1.8.555 · Cited by 486
Metadata
- Authors
- Van Obberghen-Schilling, E., Roche, N. S., Flanders, K. C., Sporn, M. B., & Roberts, A. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-06
- Volume
- 263
- Issue
- 16
- Pages
- 7741-7746
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1503388237
- Cited by
- 601
- References
- 3
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Van Obberghen-Schilling, E., Roche, N. S., Flanders, K. C., Sporn, M. B., & Roberts, A. B. (1988). Transforming growth factor beta 1 positively regulates its own expression in normal and transformed cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68561-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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