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The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.
Open accessAbstract
We have determined the complete primary structure for human matrix metalloproteinase-3 (MMP-3), which has 477 residues including a 17-residue signal peptide. The result indicates that MMP-3 is identical with stromelysin (Whitham, S. E., Murphy, G., Angel, P., Rahmsdorf, H.-J., Smith, B. J., Lyons, A., Harris, T. J. R., Reynolds, J. J., Herrlich, P., and Docherty, A. J. P. (1986) Biochem. J. 240, 913-916). A striking result is that MMP-3 and collagenase are 54% identical in sequence, suggesting a common origin for the evolution of the two proteinases. We also show that in human synovial fibroblast cultures human recombinant interleukin-1 beta rapidly induces high levels of MMP-3 mRNA and, conversely, that retinoic acid or dexamethasone can suppress the MMP-3 mRNA levels. Similar results were obtained for human synovial collagenase mRNA. The data suggest that MMP-3 and collagenase expression are coordinately modulated in synovial fibroblast cultures.
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Citations
Cited by
Physiology and pathophysiology of matrix metalloproteases
Klein, T., & Bischoff, R. (2011) · Amino Acids · doi:10.1007/s00726-010-0689-x · Cited by 828
Tissue cooperation in a proteolytic cascade activating human interstitial collagenase.
HE, C. S., Wilhelm, S. M., Pentland, A. P., Marmer, B. L., Grant, G. A., Eisen, A. Z., & Goldberg, G. I. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2632 · Cited by 572
Unemori, E. N., Ferrara, N., Bauer, E. A., & Amento, E. P. (1992) · Journal of Cellular Physiology · doi:10.1002/jcp.1041530317 · Cited by 526
A unique signature identifies a family of zinc‐dependent metallopeptidases
Jongeneel, C. V., Bouvier, J., & Bairoch, A. (1989) · FEBS Letters · doi:10.1016/0014-5793(89)80471-5 · Cited by 461
Kusano, K. (1998) · Endocrinology · doi:10.1210/en.139.3.1338 · Cited by 386
Metadata
- Authors
- Saus, J., Quinones, S., Otani, Y., Nagase, H., Harris, E. D., & Kurkinen, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-05
- Volume
- 263
- Issue
- 14
- Pages
- 6742-6745
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1491598928
- Cited by
- 223
- References
- 0
- FWCI
- 14.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Saus, J., Quinones, S., Otani, Y., Nagase, H., Harris, E. D., & Kurkinen, M. (1988). The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)68705-8
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