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Inositol phosphates: synthesis and degradation.
Open accessAbstract
phospholipase C; these topics are not considered here. This review describes the pathways and enzymes for the metabolism of inositol phosphates. myo-Inositol has six hydroxyl groups that can be substi- tuted with phosphate groups (Fig. 1). There are 63 different possible myo-inositol phosphates plus the three known ino- sitol cyclic phosphates, yielding a total of 66 possible com- pounds. Thus far, nearly 20 different inositol phosphates have been detected in one or more cell types. Many early reports describe separation of inositol mono-, bis-, and trisphosphates by step gradient elution from anion exchange resins tacitly assuming that nonspecific phosphatases acted on these com- pounds. Recent studies demonstrate that the inositol phos- phates, in fact, are metabolized by highly specific kinases and phosphatases. The complexity of the pathways for formation and degradation of these compounds leads us to speculate *
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Silverstone, P. H., O'Donnell, T., Ulrich, M., Asghar, S., & Hanstock, C. C. (2002) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.434 · Cited by 18
Metadata
- Authors
- Majerus, P. W., Connolly, T. M., Bansal, V. S., Inhorn, R. C., Ross, T. S., & Lips, D. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-03
- Volume
- 263
- Issue
- 7
- Pages
- 3051-3054
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2123771690
- Cited by
- 359
- References
- 0
- FWCI
- 23.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Majerus, P. W., Connolly, T. M., Bansal, V. S., Inhorn, R. C., Ross, T. S., & Lips, D. L. (1988). Inositol phosphates: synthesis and degradation. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)69030-1
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