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Biological Aromatization of Steroids
Open accessAbstract
The conversion of androgenic steroids to the phenolic estrogens by mammalian tissue has been well documented. The reaction has been reported in relatively low yield, in vitro with ovarian and placental slices (l-3), and in viva after the administration of androgens to various species including man (4, 5). The present report describes the conversion of androgens to estrogens in high yield by a system consisting of human placental microsomes, the reduced form of triphosphopyridine nucleotide, and oxygen. Localization of the enzymatic activity has permitted evaluation of enzyme kinetics, cofactor requirements, and substrate specificity. A preliminary note on the conversion of A4-androstene-3, 17-dione to estrone by this system has been published (6).
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Cited by
Morishima, A., Grumbach, M. M., Simpson, E. R., Fisher, C., & Qin, K. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530621 · Cited by 1,416
The Formation of Estrogens by Central Neuroendocrine Tissues
NAFTOLIN, F., RYAN, K. J., DAVIES, I. J., REDDY, V. V., FLORES, F., PETRO, Z., KUHN, M., WHITE, R. J., TAKAOKA, Y., & WOLIN, L. (1975) · Proceedings of the 1974 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571131-9.50012-8 · Cited by 793
Self-citationMcNATTY, K. P., MAKRIS, A., DEGRAZIA, C., RAPIN, O., & RYAN, K. J. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-49-5-687 · Cited by 367
Self-citationMahendroo, M. S., Mendelson, C. R., & Simpson, E. R. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36538-x · Cited by 304
The Role of Estrogen in Brain and Cognitive Aging
Russell, J. K., Jones, C. K., & Newhouse, P. A. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00766-9 · Cited by 257
Metadata
- Authors
- Ryan, K. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1959-02
- Volume
- 234
- Issue
- 2
- Pages
- 268-272
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1542371499
- Cited by
- 595
- References
- 0
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
