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ON THE MECHANISM OF THE ACONITASE AND ISOCITRIC DEHYDROGENASE REACTIONS
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The following abbreviations will be used: DPN, diphosphopyridine nucleotide; TPN, triphosphopyridine nucleotide; DPNH and TPNH, the reduced forms; DPND and TPND, reduced deuterio-DPN and reduced deuterio-TPN.2 In the experiments of San Pietro et al. (1) the added DPN was only partially reduced by the isocitric dehydrogenase-transhydrogenase system.Labeling apparently resulted from incorporation of deuterium into the remaining DPN during the boiling period after the enzyme reaction had been stopped.This interpretation is based on the following observations made during the course of the present work.1047
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“The enzyme has an asymmetric binding site for citrate, allowing the substrate to bind only in a specific orientation, so the transfer of the OH occurs only if the appropriate orientation conditions are met [112].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [112]
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Metadata
- Authors
- Englard, S., & Colowick, S. P.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1957-06
- Volume
- 226
- Issue
- 2
- Pages
- 1047-1058
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1544948283
- Cited by
- 47
- References
- 27
- Citations by year
- 2023: 1 · 2015: 1
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
- Physical Sciences › Chemistry › Organic Chemistry › Physical Organic Chemistry and Reaction Kinetics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
- Keywords
- aconitase, isocitrate dehydrogenase, reaction mechanism, deuterium labeling, diphosphopyridine nucleotide, triphosphopyridine nucleotide, enzyme kinetics
- MeSH terms
- Aconitate Hydratase, Hydro-Lyases, Isocitrate Dehydrogenase, Oxidoreductases
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