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ENZYMATIC PHOSPHORYLATION OF ACETATE
Open accessAbstract
The metabolic utilization of acetate (oxidation via the citric acid cycle, synthesis of higher fatty acids, cholesterol, and possibly other compounds) requires a preliminary activation through conversion to acetyl C0A.l Two main mechanisms are known to bring about this activation (2). One of these mechanisms, utilized by animal tissues, yeast, and some bacteria, seems to involve a single enzyme, usually referred to as the acetate activating enzyme, catalyzing the reversible conversion of ATP, acetate, and CoA to AMP, PP, and acetyl CoA (3-5). The other mechanism, which appears to be restricted to bacteria,2 involves two enzymes, acetokinase (7) and transacetylase (8), catalyzing Reactions 1 and 2 respectively. The net result is Reaction 3. A reversible reaction between ATP and acetate was first described by Lipmann in extracts of La&bacillus delbrueckii (9) and later by Stadtman and Barker in extracts of Clostridium kluyveri (10). The formation of
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Cited by
Energy conservation in chemotrophic anaerobic bacteria
Thauer, R. K., Jungermann, K., & Decker, K. (1977) · Bacteriological Reviews · doi:10.1128/br.41.1.100-180.1977 · Cited by 4,146
Wolfe, A. J. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.1.12-50.2005 · Cited by 1,233
Varma, A., & Palsson, B. O. (1994) · Applied and Environmental Microbiology · doi:10.1128/aem.60.10.3724-3731.1994 · Cited by 1,051
The Enzymic Synthesis of Amino Acyl Derivatives of Ribonucleic Acid
Berg, P., Bergmann, F. H., Ofengand, E. J., & Dieckmann, M. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)63293-x · Cited by 306
Energy Production in Anaerobic Organisms
Decker, K., Jungermann, K., & Thauer, R. K. (1970) · Angewandte Chemie International Edition in English · doi:10.1002/anie.197001381 · Cited by 203
Metadata
- Authors
- Rose, I. A., Grunberg-Manago, M., Korey, S. R., & Ochoa, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1954-12
- Volume
- 211
- Issue
- 2
- Pages
- 737-756
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1613092247
- Cited by
- 386
- References
- 0
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: ENZYMATIC PHOSPHORYLATION OF ACETATE. https://app.cochat.ai/papers/10.1016/s0021-9258(18)71161-7
- The paper
- Rose, I. A., Grunberg-Manago, M., Korey, S. R., & Ochoa, S. (1954). ENZYMATIC PHOSPHORYLATION OF ACETATE. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)71161-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
