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Platelet-activating Factor Acetylhydrolase Increases during Macrophage Differentiation
Open accessAbstract
Monocytes and macrophages produce bioactive lipids, such as platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, PAF), that mediate inflammation. These cells synthesize PAF following their activation, but not constitutively. Previous studies have demonstrated that PAF accumulation is regulated by the activity of the synthetic enzymes. We observed that the accumulation of PAF in stimulated human monocytes decreased by 90% as they differentiated into macrophages. There was no decrease in the activities of the synthetic enzymes; however, the activity of the degradative enzyme, PAF acetylhydrolase, increased 260-fold. The increase in PAF acetylhydrolase activity appeared to result from a net increase in the synthesis of a new enzyme. These studies demonstrate a novel mechanism in which an increase of the degradative enzyme regulates the accumulation of PAF. This may be an important mechanism by which macrophages modulate inflammatory responses.
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Citations
Cited by
the Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972
Dennis, E. A., Cao, J., Hsu, Y.-H., Magrioti, V., & Kokotos, G. (2011) · Chemical Reviews · doi:10.1021/cr200085w · Cited by 1,203
Prescott, S. M., Zimmerman, G. A., & McIntyre, T. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38167-5 · Cited by 889
Self-citationPlatelet-activating Factor Acetylhydrolases
Stafforini, D. M., McIntyre, T. M., Zimmerman, G. A., & Prescott, S. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.29.17895 · Cited by 270
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Xiao, Q., Pepe, A. E., Wang, G., Luo, Z., Zhang, L., Zeng, L., Zhang, Z., Hu, Y., Ye, S., & Xu, Q. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.243188 · Cited by 56
Metadata
- Authors
- Elstad, M. R., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-05
- Volume
- 264
- Issue
- 15
- Pages
- 8467-8470
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1536043153
- Cited by
- 160
- References
- 0
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Elstad, M. R., Stafforini, D. M., McIntyre, T. M., Prescott, S. M., & Zimmerman, G. A. (1989). Platelet-activating Factor Acetylhydrolase Increases during Macrophage Differentiation. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)81811-7
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