The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Calcium-activated DNA Fragmentation in Rat Liver Nuclei
Open accessAbstract
Incubation of isolated rat liver nuclei with ATP, NAD+, and submicromolar Ca2+ concentrations resulted in extensive DNA hydrolysis. Half-maximal activity occurred with 200 nM Ca2+, and saturation of the process was observed with 1 microM Ca2+. ATP stimulated a calmodulin-dependent nuclear Ca2+ uptake system which apparently mediated endonuclease activation. Ca2+-activated DNA fragmentation was inhibited by the inhibitor of poly(ADP-ribose) synthetase, 3-aminobenzamide, and was associated with poly(ADP-ribosyl)ation of nuclear protein. The characteristics of this endonuclease activity indicate that it may be responsible for the Ca2+-dependent fragmentation of DNA involved in programmed cell death (apoptosis) and in certain forms of chemically induced cell killing.
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Cites
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Self-citation
Cited by
Role of Ca2+ in toxic cell killing
Orrenius, S., McConkey, D. J., Bellomo, G., & Nicotera, P. (1989) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(89)90029-1 · Cited by 849
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The role of DNA fragmentation in apoptosis
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Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells
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Metadata
- Authors
- Jones, D. P., McConkey, D. J., Nicotera, P., & Orrenius, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 264
- Issue
- 11
- Pages
- 6398-6403
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1638280749
- Cited by
- 278
- References
- 29
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jones, D. P., McConkey, D. J., Nicotera, P., & Orrenius, S. (1989). Calcium-activated DNA Fragmentation in Rat Liver Nuclei. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)83363-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
