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Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction
Open accessAbstract
Two distinct regions of the transforming growth factor (TGF)-beta 1 promoter are responsive to autoregulation. Sequences located between nucleotides -454 to -323 and between the two major transcriptional start sites have positive regulatory activities and are induced by TGF-beta 1 in A-549 cells. The chloramphenicol acetyltransferase activity of the upstream human TGF-beta 1 promoter-chloramphenicol acetyltransferase gene is increased 8- to 10-fold by treatment of cells with TGF-beta 1, whereas that of the second promoter is increased approximately 3- to 4-fold. Using an S1 nuclease protection assay of chloramphenicol acetyl-transferase mRNA, we found that the steady-state expression of chloramphenicol acetyltransferase mRNA also is markedly increased. Seven distinct factors present in nuclear extracts from A-549 cells interact with the sequences between -454 and -323, strongly supporting the involvement of sequence-specific transcription factors in the transcriptional autoactivation of the human TGF-beta 1 gene.
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Citations
Cites
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Cited by
Fichtner-Feigl, S., Strober, W., Kawakami, K., Puri, R. K., & Kitani, A. (2006) · Nature Medicine · doi:10.1038/nm1332 · Cited by 889
The Transforming Growth Factor-βs
Roberts, A. B., & Sporn, M. B. (1990) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-49295-2_8 · Cited by 746
Self-citationTransforming Growth Factor‐β: Major Role in Regulation of Extracellular Matrix
ROBERTS, A. B., HEINE, U. I., FLANDERS, K. C., & SPORN, M. B. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb17931.x · Cited by 696
Self-citationRole of Transforming Growth Factor-beta Signaling in Cancer
de Caestecker, M. P. (2000) · Journal of the National Cancer Institute · doi:10.1093/jnci/92.17.1388 · Cited by 522
Pietenpol, J. A., Holt, J. T., Stein, R. W., & Moses, H. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.10.3758 · Cited by 398
Metadata
- Authors
- Kim, S. J., Jeang, K. T., Glick, A. B., Sporn, M. B., & Roberts, A. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 264
- Issue
- 12
- Pages
- 7041-7045
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1484049504
- Cited by
- 246
- References
- 1
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Kim, S. J., Jeang, K. T., Glick, A. B., Sporn, M. B., & Roberts, A. B. (1989). Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)83537-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
