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Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus.
Open accessAbstract
The membrane form of Trypanosoma brucei variant surface glycoprotein (mfVSG) is acylated with ester-linked tetradecanoic (myristic) acid (Ferguson, M. A. J., and Cross, G. A. M. (1984) J. Biol. Chem. 259, 3011-3015). Comparative analysis of Pronase peptides from mfVSG and soluble VSG localizes the site of mfVSG acylation to a COOH-terminal oligosaccharide structure. Chemical and enzymatic treatment of the acylated Pronase mfVSG fragment revealed that the myristic acid is present as a diglyceride (sn-1,2-dimyristin) that is probably linked to the COOH-terminal oligosaccharide via a phosphodiester bond between the sn-3-glycerol hydroxyl and a sugar hydroxyl group. The endogenous membrane-associated enzyme, which quantitatively cleaves myristic acid from mfVSG to produce soluble VSG, releases diglyceride, as would be expected of a phospholipase C.
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Cited by
Acidocalcisomes ? conserved from bacteria to man
Docampo, R., de Souza, W., Miranda, K., Rohloff, P., & Moreno, S. N. J. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1097 · Cited by 468
Ferguson, M. A., Low, M. G., & Cross, G. A. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38603-9 · Cited by 422
Self-citationDavitz, M. A., Low, M. G., & Nussenzweig, V (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.5.1150 · Cited by 353
Metadata
- Authors
- Ferguson, M. A., Haldar, K., & Cross, G. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1985-04
- Volume
- 260
- Issue
- 8
- Pages
- 4963-4968
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2156691397
- Cited by
- 268
- References
- 0
- FWCI
- 43.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus. https://app.cochat.ai/papers/10.1016/s0021-9258(18)89166-9
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- Ferguson, M. A., Haldar, K., & Cross, G. A. (1985). Trypanosoma brucei variant surface glycoprotein has a sn-1,2-dimyristyl glycerol membrane anchor at its COOH terminus. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)89166-9
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