The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes.
Open accessAbstract
For mitogenic response of macrophage-depleted human peripheral lymphocytes, 12-O-tetradecanoylphorbol-13-acetate (TPA) or 1-oleoyl-2-acetylglycerol (OAG) and Ca2+ ionophore are both needed in addition to a small quantity of plant lectin, phytohemagglutinin (PHA). PHA alone is not sufficient to produce the cellular response. The addition of TPA or OAG to these cells induces the activation of protein kinase C as assayed by the phosphorylation of its endogenous substrates. Apparently, TPA or OAG and A23187 together substitute for macrophages and act synergistically to potentiate the DNA synthesis of this lymphocyte preparation. The results suggest that protein kinase C activation and Ca2+ mobilization are essential and that additional receptor occupation by PHA is necessary for producing cell proliferation.
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Citations
Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725
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Metadata
- Authors
- Kaibuchi, K., Takai, Y., & Nishizuka, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1985-02
- Volume
- 260
- Issue
- 3
- Pages
- 1366-1369
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1557498748
- Cited by
- 215
- References
- 2
- FWCI
- 15.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kaibuchi, K., Takai, Y., & Nishizuka, Y. (1985). Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)89597-7
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