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Cited by 273

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function

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Jarabak, Joseph, Adams, Julia A., Williams-Ashman, H.G., Talalay, Paul·1962·Journal of Biological Chemistry

Abstract

This paper describes methods for the extensive purification of a soluble 17@-hydroxysteroid dehydrogenasel of human placenta. This single enzyme appears to be responsible for the entire 17/3estradiol-mediated transfer of hydrogen between pyridine nucleotides in soluble extracts of this tissue. Experiments which were reported in 1958 (2, 3) showed that soluble enzyme preparations derived from human placenta promoted a reversible transhydrogenation between pyridine nucleotides in the presence of low concentrations of 17&hydroxyst,eroids or 17-ketosteroids, notably 17/I-estradiol or estrone. These enzyme preparations also contained an active 17/3-hydroxysteroid dehydrogenase which interconverts 17@estradiol and estrone, and reacts with diphosphopyridine nucleotide (DPN) or triphosphopyridine nucleotide (TPN) (8, 9, 11). We suggested (2, 3) that the 17/3-estradiol-mediated transfer of hydro

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Metadata

Authors
Jarabak, J., Adams, J. A., Williams-Ashman, H. G., & Talalay, P.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1962-02
Volume
237
Issue
2
Pages
345-357
ISSN
0021-9258 (ISSN-L)
OpenAlex
W1528655921
Cited by
273
References
6
FWCI
6.58
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function. https://app.cochat.ai/papers/10.1016/s0021-9258(18)93926-8
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Jarabak, J., Adams, J. A., Williams-Ashman, H. G., & Talalay, P. (1962). Purification of a 17β-Hydroxysteroid Dehydrogenase of Human Placenta and Studies on Its Transhydrogenase Function. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)93926-8

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