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Metabolism of the Phenylalanine Hydroxylation Cofactor
Open accessAbstract
Abstract A simple chemical method of reducing biopterin to 7,8-dihydrobiopterin has been described. The product of this reaction appears to be identical with the phenylalanine hydroxylation cofactor isolated from rat liver extracts. With the use of the synthetic compound, the TPNH-mediated enzymatic reduction of dihydrobiopterin to the tetrahydro level has been demonstrated. This reduction is catalyzed by dihydrofolate reductase. In the presence of 7,8-dihydrobiopterin, the reductase is an essential component of the phenylalanine-hydroxylating system. The TPN-dependent oxidation of dihydrobiopterin to sepiapterin has been shown to be catalyzed by another enzyme, sepiapterin reductase.
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Cited by
Mammalian nitric oxide synthases
Stuehr, D. J. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00016-x · Cited by 996
Analysis of reduced forms of biopterin in biological tissues and fluids
Fukushima, T., & Nixon, J. C. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90336-x · Cited by 710
Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages
Kwon, N. S., Nathan, C. F., & Stuehr, D. J. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)47089-0 · Cited by 570
Shinozaki, K., Kashiwagi, A., Nishio, Y., Okamura, T., Yoshida, Y., Masada, M., Toda, N., & Kikkawa, R. (1999) · Diabetes · doi:10.2337/diabetes.48.12.2437 · Cited by 329
Metadata
- Authors
- Kaufman, S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1967-09
- Volume
- 242
- Issue
- 17
- Pages
- 3934-3943
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1669877415
- Cited by
- 180
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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