CoChat
Sign Up
Cited by 540Bone and Dental Protein StudiesBone Metabolism and DiseasesCell Adhesion Molecules Research

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Interactions between the bone matrix proteins osteopontin and bone sialoprotein and the osteoclast integrin alpha v beta 3 potentiate bone resorption

Open access
Ross, F.P., Chappel, J., Alvarez, J.I., Sander, D., Butler, W.T., Farach-Carson, M.C., Mintz, K.A., Robey, P.G., Teitelbaum, S.L., Cheresh, D.A.·1993·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)98430-9
Open this paper in CoChat — free account

Abstract

We have investigated the mechanism by which osteoclasts adhere to and resorb bone. We show that these cells express beta 1 and beta 3 integrins which are involved in attachment to purified bone matrix proteins. Binding to osteopontin and bone sialoprotein is mediated by alpha v beta 3, while a beta 1 integrin is responsible for attachment to fibronectin. Both the rapid attachment by osteoclasts to intact bone particles and their subsequent resorption are blocked by a monoclonal antibody directed to the alpha v beta 3 complex but not by an antibody against beta 1 integrins. Attachment of osteoclasts to bone is also inhibited with soluble osteopontin, Arg-Gly-Asp-containing peptides derived from both osteopontin and bone sialoprotein, or a monospecific polyclonal antibody against osteopontin. We conclude that both osteoclast adherence to bone and subsequent resorption of its matrix are dependent on interactions between the bone matrix proteins osteopontin and/or bone sialoprotein and the integrin alpha v beta 3. Moreover, collagen, which constitutes 90% of its organic matrix, is minimally involved in binding of chicken osteoclasts to bone.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)98430-9

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Chambers, 1986, Bone Miner., 1, 127
  2. Goldman, 1979, Natl. Cancer Inst., 63, 1009

Cited by

Sorted by citations

See all 540

Related

See all

Metadata

Authors
Ross, F. P., Chappel, J., Alvarez, J. I., Sander, D., Butler, W. T., Farach-Carson, M. C., Mintz, K. A., Robey, P. G., Teitelbaum, S. L., & Cheresh, D. A.
Affiliations
  • National Institutes of Health (US)
  • Scripps Research Institute (US)
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1993-05
Volume
268
Issue
13
Pages
9901-9907
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)98430-9
OpenAlex
W1511542029
Cited by
537
References
56
Citations by year
2026: 6 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 15 · 2012: 11
FWCI
28.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Biological Chemistry (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01ar039273-12)
  • National Cancer Institute (CA-50286, CA-47526)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR39273)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
osteoclasts, osteopontin, bone sialoprotein, alpha v beta 3 integrin, beta1 integrin, bone resorption, bone matrix proteins, fibronectin, RGD peptide, collagen
MeSH terms
Amino Acid Sequence, Animals, Bone Matrix, Bone Resorption, Cell Adhesion, Humans, Kinetics, Models, Biological, Molecular Sequence Data, Oligopeptides, Osteoclasts, Sialoglycoproteins, Integrins, Rats, Osteopontin, Integrin-Binding Sialoprotein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review