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Evidence for the Linkage of a Disaccharide to Hydroxylysine in Tropocollagen
Open accessAbstract
Abstract Soluble collagen from guinea pig skin has been subjected to sequential digestion with purified collagenase and trypsin. The small quantity of hexose present in the collagen can be detected in the digest largely as relatively basic glycopeptides. One of these glycopeptides has been obtained in pure form and accounts for at least 30% of the hexose of the original collagen. This glycopeptide has been shown to consist of a disaccharide of glucose and galactose linked O-glycosidically to the hydroxyl group of a hydroxylysine residue in a special peptide region of the collagen molecule. The amino acid composition and probable sequence in this region was shown to be -Gly-Met-Hyl(Glc, Gal)-Gly-His-Arg- A possible role for this structure in the formation of cross-links during collagen maturation is described.
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Citations
Cited by
Biochemical characteristics and biological significance of the genetically-distinct collagens
Miller, E. J. (1976) · Molecular and Cellular Biochemistry · doi:10.1007/bf01731779 · Cited by 462
A Heritable Disorder of Connective Tissue: Hydroxylysine-Deficient Collagen Disease
Pinnell, S. R., Krane, S. M., Kenzora, J. E., & Glimcher, M. J. (1972) · New England Journal of Medicine · doi:10.1056/nejm197205112861901 · Cited by 414
Microheterogeneity and paucidispersity of glycoproteins
Huang, C.-C., Mayer, H. E., & Montgomery, R. (1970) · Carbohydrate Research · doi:10.1016/s0008-6215(00)84902-2 · Cited by 277
Chemical, biochemical, functional, and nutritional characteristics of collagen in food systems
Asghar, A., & Henrickson, R. L. (1982) · Advances in Food Research · doi:10.1016/s0065-2628(08)60113-5 · Cited by 203
Krane, S. M., Pinnell, S. R., & Erbe, R. W. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.10.2899 · Cited by 157
Metadata
- Authors
- Butler, W. T., & Cunningham, L. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1966-09
- Volume
- 241
- Issue
- 17
- Pages
- 3882-3888
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1509313620
- Cited by
- 299
- References
- 0
- FWCI
- 21.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Butler, W. T., & Cunningham, L. W. (1966). Evidence for the Linkage of a Disaccharide to Hydroxylysine in Tropocollagen. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)99789-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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