The DOI matches its Crossref record.
Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase
Open accessAbstract
Under appropriate conditions, the activity of phosphofructokinase of skeletal muscle from frog and mouse is extremely sensitive to small changes in pH in the physiological range, a low pH decreasing the affinity of the enzyme for fructose 6-phosphate. It is concluded that shifts in intracellular pH are important in the regulation of phosphofructokinase, but that this effect makes interpretation of data from intact muscle quite difficult.
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Citations
Cited by
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches
de la Cruz-López, K. G., Castro-Muñoz, L. J., Reyes-Hernández, D. O., García-Carrancá, A., & Manzo-Merino, J. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01143 · Cited by 940
“Eukaryotic cells require the efflux of lactate and H+ to the extracellular space to prevent intracellular acidification and sustain continuously high rates of glycolysis, since the accumulation of cytosolic lactate reduces the glycolytic rate via inhibition of the rate-limiting enzyme fosfofructokinase-1 (PFK1) (82).”
BackgroundErecińska, M., & Silver, I. A. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.2 · Cited by 831
GATTUSO, J.-P., ALLEMAND, D., & FRANKIGNOULLE, M. (1999) · American Zoologist · doi:10.1093/icb/39.1.160 · Cited by 709
Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts
Moolenaar, W. H., Tsien, R. Y., van der Saag, P. T., & de Laat, S. W. (1983) · Nature · doi:10.1038/304645a0 · Cited by 707
Metadata
- Authors
- Trivedi, B., & Danforth, W. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1966-09
- Volume
- 241
- Issue
- 17
- Pages
- 4110-4114
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1641717686
- Cited by
- 669
- References
- 0
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase. https://app.cochat.ai/papers/10.1016/s0021-9258(18)99819-4
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- Trivedi, B., & Danforth, W. H. (1966). Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)99819-4
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
