Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

Wiederrecht, G; Hung, S; Chan, H.K.; Marcy, A; Martin, M; Calaycay, J; Boulton, D; Sigal, N; Kincaid, R.L.; Siekierka, J.J.

doi:10.1016/s0021-9258(19)36676-1

Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex.

The immunoregulant FK-506 potently inhibits particular calcium-associated signal transduction events that occur early during T-lymphocyte activation and during IgE receptor-mediated exocytosis in mast cells. FK-506 binds to a growing family of receptors termed FK-506-binding proteins (FKBPs), the…