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The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated.
Open accessAbstract
Rod transducin (Tr), a heterotrimeric GTP-binding protein composed of alpha, beta, and gamma subunits, couples photolysis of rhodopsin to the activation of cyclic GMP phosphodiesterase in the vertebrate visual signal transduction cascade. To determine if T alpha r is covalently modified, we analyzed tryptic fragments of bovine retinal T alpha r using electrospray mass spectrometry, liquid chromatography/mass spectrometry, tandem mass spectrometry, and gas chromatography. A novel heterogeneous fatty acylation was detected at the NH2 terminus. Four types of NH2-terminal tryptic fragments of T alpha r were isolated, and each contained either a lauroyl (C12:0), myristoyl (C14:0), (cis-delta 5)-tetradecaenoyl (C14:1) or (cis,cis-delta 5, delta 8)-tetradecadienoyl (C14:2) fatty acyl residue amide-linked to the NH2-terminal glycine residue. NH2-terminal fatty acylation does not anchor T alpha r permanently in the membrane, since T alpha r used in these experiments was eluted without detergent from rod outer segment membranes.
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Electrospray Ionization for Mass Spectrometry of Large Biomolecules
Fenn, J. B., Mann, M., Meng, C. K., Wong, S. F., & Whitehouse, C. M. (1989) · Science · doi:10.1126/science.2675315 · Cited by 7,634
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Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 788
Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase-activating protein
Palczewski, K., Subbaraya, I., Gorczyca, W. A., Helekar, B. S., Ruiz, C. C., Ohguro, H., Huang, J., Zhao, X., Crabb, J. W., Johnson, R. S., et al. (1994) · Neuron · doi:10.1016/0896-6273(94)90355-7 · Cited by 371
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Metadata
- Authors
- Neubert, T. A., Johnson, R. S., Hurley, J. B., & Walsh, K. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 267
- Issue
- 26
- Pages
- 18274-18277
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1494856533
- Cited by
- 208
- References
- 2
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Neubert, T. A., Johnson, R. S., Hurley, J. B., & Walsh, K. A. (1992). The rod transducin alpha subunit amino terminus is heterogeneously fatty acylated. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)36955-8
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