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Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter.
Open accessAbstract
A nipecotic acid-resistant gamma-aminobutyric acid (GABA) transporter was cloned from a mouse brain cDNA library. The 2.3-kilobase cDNA clone contains an open reading frame of 1842 nucleotides encoding a protein of 614 amino acids. The predicted amino acid sequence indicates it is a member of the gene family of the sodium-dependent neurotransmitter transporters. The new GABA transporter, named GAT2, is highly homologous to the betaine transporter (BGT1) cloned from canine kidney. However, GAT2 expression in the brain distinguished it from BGT1 which was exclusively expressed in the kidney. The transcripts of GAT2 were found in the cerebral cortex, cerebellum, and brainstem as well as in kidney. Expression of GAT2 in Xenopus oocytes revealed a Km of 79 microM for GABA uptake which is about 10-fold higher than that of the high affinity GABA transporter (GAT1). The pharmacology of GAT2 is different from that of GAT1 because of lack of inhibition by guvacine and nipecotic acid and sensitivity to high concentrations of betaine and beta-alanine. GAT2 transports betaine with a Km of about 200 microM, but no significant transport of beta-alanine could be detected. The presence of mRNA encoding GAT2 in parts of the brain suggests it is a neurotransmitter transporter.
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Cited by
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114
Liu, X., Wang, Q., Haydar, T. F., & Bordey, A. (2005) · Nature Neuroscience · doi:10.1038/nn1522 · Cited by 444
Influence of glutamate and GABA transport on brain excitatory/inhibitory balance
Sears, S. M., & Hewett, S. J. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221989263 · Cited by 336
Guimbal, C., & Kilimann, M. W. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)52891-x · Cited by 298
Liu, Q. R., López-Corcuera, B., Mandiyan, S., Nelson, H., & Nelson, N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41598-0 · Cited by 277
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Metadata
- Authors
- Lopez-Corcuera, B., Liu, Q. R., Mandiyan, S., Nelson, H., & Nelson, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-09
- Volume
- 267
- Issue
- 25
- Pages
- 17491-17493
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1550534589
- Cited by
- 210
- References
- 0
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lopez-Corcuera, B., Liu, Q. R., Mandiyan, S., Nelson, H., & Nelson, N. (1992). Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)37067-x
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