The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel
Open accessAbstract
A highly conserved position of negatively charged amino acids is present in the SS2 segments of the S5-S6 linker regions among calcium channels. We report here that replacing Glu residues at this position alters the ion selectivity of the human cardiac calcium channel. Substituting Glu334 in motif I or Glu1086 in motif III with Lys produced mutant calcium channels that permeated sodium ions 10-fold more effectively than barium ions. More conservative changes such as substitution of Glu1086 with Gln or substitution of Glu1387 with Ala also increased sodium permeation through the mutant calcium channels. Sodium currents through the mutant calcium channels could be modulated by dihydropyridines and blocked by external divalent cations. These results suggest that Glu334, Glu1086, and Glu1387 are part of a ring of glutamate residues formed in the pore-lining SS1-SS2 region and are critical in determining ion selectively and permeability of a human cardiac calcium channel.
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Cites
Calcium channel characteristics conferred on the sodium channel by single mutations
Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K., & Numa, S. (1992) · Nature · doi:10.1038/356441a0 · Cited by 784
Cited by
Absence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects
Fletcher, C. F., Lutz, C. M., O'Sullivan, T. N., Shaughnessy, J. D., Hawkes, R., Frankel, W. N., Copeland, N. G., & Jenkins, N. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81381-1 · Cited by 772
Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C
Kamp, T. J., & Hell, J. W. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1095 · Cited by 606
CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel
Vig, M., Beck, A., Billingsley, J. M., Lis, A., Parvez, S., Peinelt, C., Koomoa, D. L., Soboloff, J., Gill, D. L., Fleig, A., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.085 · Cited by 554
Control of aldosterone secretion: a model for convergence in cellular signaling pathways
SPÄT, A., & HUNYADY, L. (2004) · Physiological Reviews · doi:10.1152/physrev.00030.2003 · Cited by 494
Raffaello, A., De Stefani, D., Sabbadin, D., Teardo, E., Merli, G., Picard, A., Checchetto, V., Moro, S., Szabò, I., & Rizzuto, R. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.157 · Cited by 490
Metadata
- Authors
- Tang, S., Mikala, G., Bahinski, A., Yatani, A., Varadi, G., & Schwartz, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 268
- Issue
- 18
- Pages
- 13026-13029
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1685356864
- Cited by
- 171
- References
- 1
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tang, S., Mikala, G., Bahinski, A., Yatani, A., Varadi, G., & Schwartz, A. (1993). Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)38613-2
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