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Cited by 253

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Phospholipid Exchange between Membranes

Open access
Helmkamp, George M., Harvey, Mark S., Wirtz, Karel W.A., van Deenen, Laurens L.M.·1974·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)42169-8
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Abstract

Using an assay that measures the transfer of phosphatidyl-[3H]inositol from rat liver microsomes to liposomes consisting of phosphatidylcholine (98 mole %) and phosphatidylinositol (2 mole %), two proteins have been isolated from homogenates of bovine brain cortical tissue which specifically stimulate the above phospholipid exchange. Protein I, purified 508-fold, has a molecular weight of approximately 29,000 and an isoelectric point of 5.2, and protein II, purified 426-fold, has a molecular weight of approximately 30,000 and an isoelectric point of 5.5. Among the phospholipids examined in various transfer systems, both proteins exhibited a marked preference for phosphatidylinositol transfer; phosphatidylcholine, but not phosphatidylethanolamine, could also be transferred between membranes. The capacities to transfer phosphatidylinotisol and phosphatidylcholine were inhibited simultaneously by tryptic degradation of each protein; however, protein II was significantly more sensitive to this treatment than protein I. The effects of membrane concentration (microsomal protein or liposomal phospholipid) on relative rates of phosphatidylinositol transfer have been determined. Estimations of Km and V with respect to each membrane have been made. These properties of the brain phospholipid transfer proteins are discussed in relationship to those of other proteins which function in the redistribution of phospholipid between membranes.

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Metadata

Authors
Helmkamp, G. M., Harvey, M. S., Wirtz, K. W. A., & van Deenen, L. L. M.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1974-10
Volume
249
Issue
20
Pages
6382-6389
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)42169-8
OpenAlex
W1566203574
Cited by
253
References
25
FWCI
4.79
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Phospholipid Exchange between Membranes. https://app.cochat.ai/papers/10.1016/s0021-9258(19)42169-8
The paper
Helmkamp, G. M., Harvey, M. S., Wirtz, K. W. A., & van Deenen, L. L. M. (1974). Phospholipid Exchange between Membranes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)42169-8

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.