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Cited by 191

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Regulation of Hemoglobin Synthesis

Open access
Lodish, Harvey F., Jacobsen, Marion·1972·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(19)45186-7
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Abstract

We find no difference in the rate of translation of OL-and /3-globin mRNA in cell-free extracts of rabbit reticulocytes (about 200 s per chain at 25") nor in the rate of release of completed globin chains from polyribosomes (about 15 s per chain).In these reactions, as well as incubation of intact reticulocytes, each /3-globin mRNA contains 30 to 40% more ribosomes than each oc-mRNA.These results imply that each /3-mRNA initiates synthesis of about 40% more p-globin than each ol-mRNA initiates synthesis of a! chains.Hence, reticulocytes must contain 30 to 40% more ar-mRNA than /3 in order to synthesize equal numbers of the two hemoglobin chains.This conclusion is consistent with results of a previous indirect measure of the relative amounts of CYand P-globin mRNA (Lodish, H. F.

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Metadata

Authors
Lodish, H. F., & Jacobsen, M.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1972-06
Volume
247
Issue
11
Pages
3622-3629
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(19)45186-7
OpenAlex
W1554943836
Cited by
191
References
0
FWCI
6.64
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Regulation of Hemoglobin Synthesis. https://app.cochat.ai/papers/10.1016/s0021-9258(19)45186-7
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Lodish, H. F., & Jacobsen, M. (1972). Regulation of Hemoglobin Synthesis. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)45186-7

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