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Inhibition of mucin glycosylation by aryl-N-acetyl-α-galactosaminides in human colon cancer cells
Open accessAbstract
Specific inhibitors of the glycosylation of O-glycosidically linked glycoproteins have not previously been described. When tested for their effects on mucin glycosylation in a mucin-producing colon cancer cell line, LS174T, benzyl-, phenyl-, and p-nitrophenyl-N-acetyl-alpha-galactosaminide inhibited the formation of fully glycosylated mucin in a dose-dependent manner. Free aryl-oligosaccharides were found in the medium of treated cells labeled with [3H]glucosamine, [3H]galactose, [3H]fucose, [3H]mannosamine, or phenyl-alpha-[6-3H] N-acetylgalactosamine. UDP-Gal:GalNAc-beta 1,3-galactosyltransferase was inhibited by aryl-N-acetyl-alpha-galactosaminides but not by a number of other aryl-glycosides. Treatment with these inhibitors also causes reversible morphologic changes including formation of intercellular cysts. Aryl-N-acetyl-alpha-galactosaminides can be useful for the structural and functional studies of mucin macromolecules and other O-linked glycoproteins.
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Colorimetric Method for Determination of Sugars and Related Substances
DuBois, M., Gilles, K. A., Hamilton, J. K., Rebers, P. A., & Smith, F. (1956) · Analytical Chemistry · doi:10.1021/ac60111a017 · Cited by 52,269
Cited by
Fucosylation and protein glycosylation create functional receptors for cholera toxin
Wands, A. M., Fujita, A., McCombs, J. E., Cervin, J., Dedic, B., Rodriguez, A. C., Nischan, N., Bond, M. R., Mettlen, M., Trudgian, D. C., et al. (2015) · eLife · doi:10.7554/elife.09545 · Cited by 90
Metadata
- Authors
- Kuan, S. F., Byrd, J. C., Basbaum, C., & Kim, Y. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1989-11
- Volume
- 264
- Issue
- 32
- Pages
- 19271-19277
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1670186976
- Cited by
- 265
- References
- 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Inhibition of mucin glycosylation by aryl-N-acetyl-α-galactosaminides in human colon cancer cells. https://app.cochat.ai/papers/10.1016/s0021-9258(19)47297-9
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- Kuan, S. F., Byrd, J. C., Basbaum, C., & Kim, Y. S. (1989). Inhibition of mucin glycosylation by aryl-N-acetyl-α-galactosaminides in human colon cancer cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)47297-9
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