The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Dietary regulation of stearoyl-CoA desaturase 1 gene expression in mouse liver.
Open accessAbstract
Expression of the murine liver stearoyl-CoA desaturase gene (SCD1) is induced upon feeding fasted mice a fat-free, high carbohydrate diet (Ntambi, J. M., Buhrow, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., Kelly, T. J., and Lane, M.D. (1988) J. Biol. Chem. 263, 17291-17300). In the present study, SCD1-specific RNA riboprobes and cDNA probes were used to study the mechanism for the induction of SCD1 mRNA. Based on the time course of induction, the SCD1 mRNA increased from 2-fold within 6 h to 45-fold within 36 h. Nuclear run-on transcription studies showed that the accumulation of SCD1 mRNA after refeeding starved mice a fat-free, high carbohydrate diet was a consequence of the transcriptional activation of the SCD1 gene. The SCD1 mRNA level decreased rapidly (t1/2 = approximately 4 h) within 24 h when mice fed the fat-free, high carbohydrate diet were switched to a regular chow diet. Furthermore, when the fat-free diet was supplemented with triacylglycerides containing polyunsaturated fatty acids, the transcription of the SCD1 gene and the induction of the SCD1 mRNA were significantly blunted. Triacylglycerides containing saturated and monounsaturated fatty acids were without dramatic effects. In contrast, synthesis of liver albumin mRNA was little affected by any of these dietary variations, indicating that the observed changes in the transcription of the SCD1 gene and mRNA levels were specific. These data demonstrate that both dietary carbohydrates and polyunsaturated fatty acids or their metabolites directly or indirectly regulate the expression of the SCD1 gene in mouse liver.
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Cites
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
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A rapid alkaline extraction procedure for screening recombinant plasmid DNA
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Lamers, W. H., Hanson, R. W., & Meisner, H. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.17.5137 · Cited by 402
Differentiation-induced Gene Expression in 3T3-L1 Preadipocytes
Kaestner, K. H., Ntambi, J. M., Kelly, T. J., & Lane, M. D. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63763-9 · Cited by 371
Self-citationNtambi, J. M., Buhrow, S. A., Kaestner, K. H., Christy, R. J., Sibley, E., Kelly, T. J., & Lane, M. D. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77834-x · Cited by 354
Self-citationHormonal Regulation of Mouse Fatty Acid Synthase Gene Transcription in Liver
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Cited by
Postic, C., & Girard, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34275 · Cited by 1,204
Regulation of stearoyl-CoA desaturases and role in metabolism
Ntambi, J. (2004) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00039-0 · Cited by 710
Self-citationStructure and expression of fatty acid desaturases
Los, D. A., & Murata, N. (1998) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(98)00091-5 · Cited by 558
POLYUNSATURATED FATTY ACID REGULATION OF GENES OF LIPID METABOLISM
Sampath, H., & Ntambi, J. M. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.25.051804.101917 · Cited by 555
Self-citationXu, J., Nakamura, M. T., Cho, H. P., & Clarke, S. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23577 · Cited by 499
Metadata
- Authors
- Ntambi, J. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1992-05
- Volume
- 267
- Issue
- 15
- Pages
- 10925-10930
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1488738929
- Cited by
- 277
- References
- 24
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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