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Glutathione S-transferases, structure, regulation, and therapeutic implications
Open accessAbstract
The glutathione S-transferases (GSTs)' are a family of enzymes that catalyze the nucleophilic addition of the thiol of reduced glutathione to a variety of electrophiles (1-9). In addition, the GSTs bind with varying affinities a variety of hydrophobic compounds such as heme, bilirubin, polycyclic aromatic hydrocarbons, and dexamethasone (1-9). It is now generally accepted that the GSTs are encoded by at least five different gene families (9-12). Four of the gene families encode the cytosolic GSTs whereas the fifth en-codes a microsomal form of the enzyme (13, 14). In this review, we have focused on three GST research areas: 1) structure-function analysis of GSTs; 2) regulation of GST expression; and 3) GSTs as therapeutic targets in disease. Since our review will not be com-prehensive, we would like to direct the reader to several excellent recent reviews focusing on various aspects of GSTs (4,8,9).
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Cited by
Nrf2:INrf2 (Keap1) signaling in oxidative stress
Kaspar, J. W., Niture, S. K., & Jaiswal, A. K. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.07.035 · Cited by 1,648
Nrf2 signaling in coordinated activation of antioxidant gene expression
Jaiswal, A. K. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.02.074 · Cited by 1,254
Tomarev, S. I., & Piatigorsky, J. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00449.x · Cited by 146
IKEDA, H., NISHI, S., & SAKAI, M. (2004) · Biochemical Journal · doi:10.1042/bj20031948 · Cited by 136
Presence and induction of the enzyme NAD(P)H: Quinone oxidoreductase 1 in the central nervous system
Stringer, J. L., Gaikwad, A., Gonzales, B. N., Long, D. J., Marks, L. M., & Jaiswal, A. K. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20048 · Cited by 41
Metadata
- Authors
- Rushmore, T. H., & Pickett, C. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 268
- Issue
- 16
- Pages
- 11475-11478
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1486158855
- Cited by
- 405
- References
- 0
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Rushmore, T. H., & Pickett, C. B. (1993). Glutathione S-transferases, structure, regulation, and therapeutic implications. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)50219-8
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