The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A
Open accessAbstract
In patch-clamp experiments on rat liver mitoplasts, cyclosporin A inhibited the activity of the recently described (Petronilli, V., Szabó, I., and Zoratti, M. (1989) FEBS Lett. 259, 137-143) 1.3-nanosiemens channel of the inner mitochondrial membrane at concentrations in the 10(-8)-10(-7) M range. The inhibitor acts when present on the matrix side of membrane. The Ca2(+)-dependent "permeability transition channel" of mitochondria is inhibited by cyclosporin A in the same concentration range. The results suggest therefore that the same pore is responsible for the permeabilization of the inner mitochondrial membrane and for the conduction of the high currents observed in electrophysiological experiments.
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Citations
Cites
Mechanisms by which mitochondria transport calcium
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Crompton, M., Ellinger, H., & COSTI, A. (1988) · PubMed Central · Cited by 841
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Broekemeier, K. M., Dempsey, M. E., & Pfeiffer, D. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83116-7 · Cited by 699
Mitochondrial calcium transport
Nicholls, D., & Åkerman, K. (1982) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(82)90013-1 · Cited by 482
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Action of cyclosporine on mitochondrial calcium fluxes
Fournier, N., Ducet, G., & Crevat, A. (1987) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762419 · Cited by 337
CROMPTON, M., & COSTI, A. (1988) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1988.tb14475.x · Cited by 297
Patch-clamping of the inner mitochondrial membrane reveals a voltage-dependent ion channel
Sorgato, M. C., Keller, B. U., & Stühmer, W. (1987) · Nature · doi:10.1038/330498a0 · Cited by 243
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Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383
The mitochondrial permeability transition pore and its role in cell death
CROMPTON, M. (1999) · Biochemical Journal · doi:10.1042/bj3410233 · Cited by 2,432
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Lemasters, J. J., Nieminen, A.-L., Qian, T., Trost, L. C., Elmore, S. P., Nishimura, Y., Crowe, R. A., Cascio, W. E., Bradham, C. A., Brenner, D. A., et al. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(98)00112-1 · Cited by 1,387
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Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.04.029 · Cited by 1,077
Metadata
- Authors
- Szabó, I., & Zoratti, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 266
- Issue
- 6
- Pages
- 3376-3379
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1500217596
- Cited by
- 370
- References
- 24
- FWCI
- 6.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Szabó, I., & Zoratti, M. (1991). The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)67802-6
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
