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Mammalian Liver Phosphoenolpyruvate Carboxykinase Activities
Open accessAbstract
During an investigation of factors affecting phosphopyruvate formation from a-ketoglutarate by liver mitochondria (1, 2) great differences were found between species.’ Mitochondria from livers of guinea pigs, like those from rabbits (a), formed phosphoenolpyruvate in large amounts whereas similar preparations from rat livers formed relatively minor am0unts.r As has been suggested (2) and substantiated by us,l phosphoenolpyruvate carboxykinase (3) (GTP : oxalacetate carboxy-lyase (transphosphorylating); I.U.B., EC 4.1.1.32) could be involved in the over-all formation of phosphoenolpyruvate (P-enolpyruvate) starting with a-ketoglutarate and orthophosphate under aerobic conditions, in the presence of 2,4-dinitrophenol, by catalyzing Reaction 1.
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Cited by
Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver
Ballard, F., & Hanson, R. (1967) · Biochemical Journal · doi:10.1042/bj1040866 · Cited by 408
Metabolic Control of Enzymes Involved in Lipogenesis and Gluconeogenesis*
Young, J. W., Shrago, E., & Lardy, H. A. (1964) · Biochemistry · doi:10.1021/bi00899a015 · Cited by 358
Self-citationTuo, L., Xiang, J., Pan, X., Hu, J., Tang, H., Liang, L., Xia, J., Hu, Y., Zhang, W., Huang, A., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1029-y · Cited by 84
Metadata
- Authors
- Nordlie, R. C., & Lardy, H. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1963-07
- Volume
- 238
- Issue
- 7
- Pages
- 2259-2263
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1509668278
- Cited by
- 375
- References
- 0
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Nordlie, R. C., & Lardy, H. A. (1963). Mammalian Liver Phosphoenolpyruvate Carboxykinase Activities. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)67962-7
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