The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.
Open accessAbstract
"Activated bleomycin" is an oxygenated iron drug complex which embodies the drug's DNA-cleaving activity. This activity is exercised on DNA, if present, but if DNA is absent, the drug itself is inactivated. Hyperfine interactions in the EPR spectra of activated bleomycin prepared with 57Fe(II) and 17O2 demonstrate the presence of iron as Fe(III) and of bound oxygen originating in dioxygen. Bleomycin can also be activated with Fe(III) and either H2O2 or ethyl hydroperoxide. These latter reactions do not produce a ferrous intermediate nor do they require O2. But O2 is required for the reaction of activated bleomycin with DNA to yield the malondialdehyde-like chromogens used to monitor DNA degradation. The attack on DNA is quantitatively concurrent with the decay of activated bleomycin, however generated.
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Citations
Cites
Oxygen Activation by Cytochrome P-4501
White, R. E., & Coon, M. J. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.001531 · Cited by 1,023
Cited by
Reactions of oxyl radicals with DNA
Breen, A. P., & Murphy, J. A. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)00209-3 · Cited by 1,038
Pogozelski, W. K., & Tullius, T. D. (1998) · Chemical Reviews · doi:10.1021/cr960437i · Cited by 1,018
Chevion, M. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90059-7 · Cited by 508
Chen, K., & Que, L. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010310x · Cited by 485
Iyanagi, T. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(06)60002-8 · Cited by 290
Metadata
- Authors
- Burger, R. M., Peisach, J., & Horwitz, S. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1981-11
- Volume
- 256
- Issue
- 22
- Pages
- 11636-11644
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1521920054
- Cited by
- 462
- References
- 1
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Burger, R. M., Peisach, J., & Horwitz, S. B. (1981). Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)68452-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
