The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Release and metabolism of arachidonic acid in human neutrophils.
Open accessAbstract
Dual radiolabel incorporation of [3H]arachidonic acid and [14C]palmitate or [14C]stearate by human neutrophils was employed to study both the release and metabolism of arachidonic acid. Results indicate the involvement of a phospholipase A2 mechanism causing [3H]arachidonate release from membrane phospholipid. Phosphatidylinositol and phosphatidylcholine were the sources of [3H]arachidonate; about twice as much radiolabeled phosphatidylinositol was degraded as phosphatidylcholine. Challenge of neutrophils with opsonized zymosan and calcium ionophores caused the release of [3H]arachidonate; however, ionophores but not opsonized zymosan led to the production of [3H]hydroxyicosatetraenoic acid and [3H]dihydroxyicosatetraenoic acid. These products were preferentially released by neutrophils into the extracellular milieu in contrast with free [3H]arachidonate which remained cell associated. One-third of the [3H]hydroxyicosatetraenoic acid but not [3H]dihydroxyicosatetraenoic acid was reincorporated into cellular lipid, primarily phospholipid. No significant production of [3H]prostaglandin or [3H]thromboxane was detected. In contrast to zymosan and ionophore, phorbol myristate acetate, another potent stimulant of neutrophil oxidative metabolism and degranulation, did not release [3H]arachidonate.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cited by
Castagna, M., Takai, Y., Kaibuchi, K., Sano, K., Kikkawa, U., & Nishizuka, Y. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34459-4 · Cited by 4,725
Channon, J. Y., & Leslie, C. C. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)39374-3 · Cited by 441
Metadata
- Authors
- Walsh, C. E., Waite, B. M., Thomas, M. J., & DeChatelet, L. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1981-07
- Volume
- 256
- Issue
- 14
- Pages
- 7228-7234
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1568917698
- Cited by
- 279
- References
- 1
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Walsh, C. E., Waite, B. M., Thomas, M. J., & DeChatelet, L. R. (1981). Release and metabolism of arachidonic acid in human neutrophils. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)68951-9
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