The DOI matches its Crossref record.
1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells.
Open accessAbstract
Rat osteosarcoma cells respond to 1,25-dihydroxyvitamin D3 with a 6-fold increase in intracellular and secreted levels of the vitamin K-dependent protein of bone (BGP). The rise in intracellular BGP levels is half-maximal at 6.6 h and precedes the rise in medium BGP levels by 6 h, a time course which is consistent with the postulated steroid hormone action of 1,25-dihydroxyvitamin D3. This effect is achieved by physiological levels of 1,25-dihydroxyvitamin D3, with half of the maximal response at a vitamin concentration of 0.04 ng/ml. The specificity of this effect for BGP is demonstrated by the absence of a 1,25-dihydroxyvitamin D3 effect on total protein synthesis by these cells. To our knowledge, BGP is the first example of a bone protein whose rate of synthesis is dramatically and specifically increased by physiological levels of 1,25-dihydroxyvitamin D3. The possible functions of BGP in the biological actions of 1,25-dihydroxyvitamin D3 on bone are discussed.
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Cited by
Molecular and cellular biology of alveolar bone
SODEK, J., & MCKEE, M. D. (2000) · Periodontology 2000 · doi:10.1034/j.1600-0757.2000.2240106.x · Cited by 283
Osteoporosis after spinal cord injury.
Jiang, S.-D., Dai, L.-Y., & Jiang, L.-S. (2006) · Osteoporosis International · doi:10.1007/s00198-005-2028-8 · Cited by 282
Vitamin K Nutrition and Osteoporosis
Binkley, N. C., & Suttie, J. W. (1995) · The Journal of Nutrition · doi:10.1093/jn/125.7.1812 · Cited by 185
Douglas, A. S., Robins, S. P., Hutchison, J. D., Porter, R. W., Stewart, A., & Reid, D. M. (1995) · Bone · doi:10.1016/8756-3282(95)00133-x · Cited by 86
Differences in basal and postexercise osteocalcin levels in athletic and nonathletic humans
Nishiyama, S., Tomoeda, S., Ohta, T., Higuchi, A., & Matsuda, I. (1988) · Calcified Tissue International · doi:10.1007/bf02571312 · Cited by 86
Sutton, A. L. M., Zhang, X., Dowd, D. R., Kharode, Y. P., Komm, B. S., & MacDonald, P. N. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0363 · Cited by 61
Decreased serum osteocalcin levels in patients with liver cirrhosis
Pietschmann, P., Resch, H., Müller, C., Woloszczuk, W., & Willvonseder, R. (1990) · Bone and Mineral · doi:10.1016/0169-6009(90)90113-t · Cited by 28
Metadata
- Authors
- Price, P. A., & Baukol, S. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-12
- Volume
- 255
- Issue
- 24
- Pages
- 11660-11663
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1605030605
- Cited by
- 500
- References
- 0
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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