The DOI matches its Crossref record.
Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum.
Open accessAbstract
Electrode measurements were made of the free Ca2+ concentration maintained by suspensions of isolated rat liver mitochondria and microsomes, as well as by hepatocytes whose plasma membranes had been made permeable by treatment with digitonin. When the KCl, ATP, Mg2+, and phosphate concentrations were made similar to that of cytosol, the steady state free Ca2+ concentration in the presence of respiring mitochondria alone was about 0.5 microM. The additional presence of rat liver microsomes resulted in a steady state level of close to 0.2 microM, which was maintaied for greater than 1 h at 25 degrees C. This concentration of Ca2+ was also maintained by suspensions of hepatocytes permeabilized by digitonin and thus may approximate the actual cytosolic free Ca2+ concentration in vivo. The "set point" for free Ca2+ homeostasis in these systems is determined by mitochondrial Ca2+ influx-efflux cycling, which is dependent on the level of intramitochondrial Ca2+ and can be adjusted by sequestration of Ca2+ in microsomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mechanisms by which mitochondria transport calcium
Gunter, T. E., & Pfeiffer, D. R. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.5.c755 · Cited by 1,640
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
Voltage-dependent anion channel (VDAC) as mitochondrial governator—Thinking outside the box
Lemasters, J. J., & Holmuhamedov, E. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.10.006 · Cited by 434
Relation between mitochondrial calcium transport and control of energy metabolism
Hansford, R. G. (1985) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0034084 · Cited by 370
Role of calcium in the hormonal regulation of liver metabolism
Williamson, J. R., Cooper, R. H., & Hoek, J. B. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90012-4 · Cited by 317
Metadata
- Authors
- Becker, G. L., Fiskum, G., & Lehninger, A. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-10
- Volume
- 255
- Issue
- 19
- Pages
- 9009-9012
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1566063705
- Cited by
- 254
- References
- 0
- FWCI
- 11.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum. https://app.cochat.ai/papers/10.1016/s0021-9258(19)70515-8
- The paper
- Becker, G. L., Fiskum, G., & Lehninger, A. L. (1980). Regulation of free Ca2+ by liver mitochondria and endoplasmic reticulum. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)70515-8
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
