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Vitamin D-binding protein (Gc-globulin) binds actin.
Open accessAbstract
Actin, an ubiquitous highly conserved intracellular protein, and the serum vitamin D-binding protein (DBP) form tight 1:1 molar complexes in vitro. This interaction, which is not species-specific, explains the widespread occurrence of the 5-6 S protein responsible for the binding of 25-hydroxycholecalciferol in high speed supernatants of all nucleated tissues. Incubation of F-actin, the filamentous form of this protein, with DBP leads to depolymerization of the former. Actin, complexed with deoxyribonuclease I, retains its ability to bind DBP. Erythrocyte actin, prepared from red cell ghosts, also displays binding properties for DBP. The biological significance of this new interaction of actin is not yet understood.
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Cited by
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Self-citationBiological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism
Speeckaert, M., Huang, G., Delanghe, J. R., & Taes, Y. E. C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.03.011 · Cited by 480
Vitamin D Binding Protein: A Historic Overview
Bouillon, R., Schuit, F., Antonio, L., & Rastinejad, F. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00910 · Cited by 316
Self-citationBraun, A., Bichlmaier, R., & Cleve, H. (1992) · Human Genetics · doi:10.1007/bf00194311 · Cited by 137
Metadata
- Authors
- Van Baelen, H., Bouillon, R., & De Moor, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1980-03
- Volume
- 255
- Issue
- 6
- Pages
- 2270-2272
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2166659336
- Cited by
- 283
- References
- 0
- FWCI
- 14.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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