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In vitro effects of palmitylcarnitine on cardiac plasma membrane Na,K-ATPase, and sarcoplasmic reticulum Ca2+-ATPase and Ca2+ transport.
Open accessAbstract
hkhir IUUSCle. LOW COnCeUbi~iOUS (5 t0 50 pM) Of palmitylcarnitine enhance Ca2+-ATPase activity and Ca2+ binding to sarcoplasmic reticulum and enhance [3H]ouabain binding to Na,K-ATPase above equilibrium binding levels but inhibit Na,K-ATPase hydrolytic activity. Increasing concentrations of palmitylcarnitine (50 to 200 PM) further inhibit Na,K-ATPase activity and markedly decrease the binding of [3H]ouabain to this enzyme. Sarcoplasmic reticulum Ca2+-ATPase activity and Ca2+ binding are similarly inhibited by these higher concentrations of palmitylcarnitine. Palmitylcarnitine also produced concentration-dependent changes in the fluorescence intensity of a lipidbound fluorescent probe, dansyl (5-dimethylaminonaphthalene lsulfonyl) phosphatidylethanolamine, which was incorporated into sarcoplasmic reticulum and Na,K-ATPase membranes. Palmitylcarnitine induced an enhancement of fluorescence in both membrane systems and this enhancement of fluorescence was linearly related to the inhibition of Na,K-ATPase activity. The biphasic action of palmitylcarnitine on the functional properties of sarcoplasmic reticulum and Na,KATPase resembles the actions of detergents on these membrane systems. Palmitylcarnitine is considered to act as a naturally occurring detergent and a mechanism is proposed to explain its actions in uitro.
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Citations
Cited by
Carnitine—metabolism and functions
Bremer, J. (1983) · Physiological Reviews · doi:10.1152/physrev.1983.63.4.1420 · Cited by 1,666
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Katz, A. M., & Messineo, F. C. (1981) · Circulation Research · doi:10.1161/01.res.48.1.1 · Cited by 607
Regulation of fatty acid oxidation in the mammalian heart in health and disease
Lopaschuk, G. D., Belke, D. D., Gamble, J., Toshiyuki, I., & Schönekess, B. O. (1994) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(94)00082-4 · Cited by 554
Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials
Dambrova, M., Makrecka-Kuka, M., Kuka, J., Vilskersts, R., Nordberg, D., Attwood, M. M., Smesny, S., Sen, Z. D., Guo, A. C., Oler, E., et al. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000408 · Cited by 507
Jones, L. L., McDonald, D. A., & Borum, P. R. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.08.004 · Cited by 454
Metadata
- Authors
- Adams, R. J., Cohen, D. W., Gupte, S., Johnson, J. D., Wallick, E. T., Wang, T., & Schwartz, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-12
- Volume
- 254
- Issue
- 24
- Pages
- 12404-12410
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1029688286
- Cited by
- 169
- References
- 0
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Adams, R. J., Cohen, D. W., Gupte, S., Johnson, J. D., Wallick, E. T., Wang, T., & Schwartz, A. (1979). In vitro effects of palmitylcarnitine on cardiac plasma membrane Na,K-ATPase, and sarcoplasmic reticulum Ca2+-ATPase and Ca2+ transport. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(19)86329-9
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