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The earliest changes in gene expression in tadpole intestine induced by thyroid hormone.
Open accessAbstract
Genes induced by thyroid hormone (TH) to change their expression in the Xenopus laevis gastrointestinal (GI) tract have been isolated using a subtractive hybridization method. An exhaustive search for down-regulated genes identified a single gene. Thirty-two different cDNA fragments derived from the up-regulated mRNA of tadpole intestine 18 h after addition of TH were cloned. They map to no more than 22 distinct genes. The isolation of multiple cDNA fragments derived from a single mRNA indicates that the complexity of up-regulated genes is limited. Both ubiquitous and intestine-specific up-regulated genes were found in this screen. The majority of these genes respond directly to TH induction as judged by the resistance of up-regulation to inhibitors of protein synthesis. The biological significance of these genes is supported by their dramatic regulation in the GI tract during spontaneous metamorphosis.
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Cited by
Brown, D. D., & Cai, L. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.03.021 · Cited by 498
Self-citationSteroid regulated programmed cell death during Drosophila metamorphosis
Jiang, C., Baehrecke, E. H., & Thummel, C. S. (1997) · Development · doi:10.1242/dev.124.22.4673 · Cited by 391
Local impact of thyroid hormone inactivation
Dentice, M., & Salvatore, D. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0002 · Cited by 143
Metadata
- Authors
- Shi, Y. B., & Brown, D. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1993-09
- Volume
- 268
- Issue
- 27
- Pages
- 20312-20317
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1663165115
- Cited by
- 184
- References
- 0
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shi, Y. B., & Brown, D. D. (1993). The earliest changes in gene expression in tadpole intestine induced by thyroid hormone. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(20)80730-3
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