The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
In vitro modeling of human tibial strains during exercise in micro-gravity
Abstract
Prolonged exposure to micro-gravity causes substantial bone loss (Leblanc et al., Journal of Bone Mineral Research 11 (1996) S323) and treadmill exercise under gravity replacement loads (GRLs) has been advocated as a countermeasure. To date, the magnitudes of GRLs employed for locomotion in space have been substantially less than the loads imposed in the earthbound 1G environment, which may account for the poor performance of locomotion as an intervention. The success of future treadmill interventions will likely require GRLs of greater magnitude. It is widely held that mechanical tissue strain is an important intermediary signal in the transduction pathway linking the external loading environment to bone maintenance and functional adaptation; yet, to our knowledge, no data exist linking alterations in external skeletal loading to alterations in bone strain. In this preliminary study, we used unique cadaver simulations of micro-gravity locomotion to determine relationships between localized tibial bone strains and external loading as a means to better predict the efficacy of future exercise interventions proposed for bone maintenance on orbit. Bone strain magnitudes in the distal tibia were found to be linearly related to ground reaction force magnitude (R(2)>0.7). Strain distributions indicated that the primary mode of tibial loading was in bending, with little variation in the neutral axis over the stance phase of gait. The greatest strains, as well as the greatest strain s…
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“The study results of Peterman et al. (2001) reveal that bone strain magnitudes in the distal tibia are linearly related to GRF (R2 > 0.7) (Peterman et al., 2001)”
From Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review (2017) · cites this paper as Peterman et al., 2001
Citations
Cites
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Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review
Richter, C., Braunstein, B., Winnard, A., Nasser, M., & Weber, T. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00583 · Cited by 75
Metadata
- Authors
- Peterman, M. M., Hamel, A. J., Cavanagh, P. R., Piazza, S. J., & Sharkey, N. A.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Sharkey, Neil A.
- Venue
- Journal of Biomechanics
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 34
- Issue
- 5
- Pages
- 693-698
- ISSN
- 0021-9290 (ISSN-L)
- OpenAlex
- W1988627989
- Cited by
- 50
- References
- 15
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 2 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomechanics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Core Research for Evolutional Science and Technology
- Topics
- Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Effects of Vibration on Health
- Keywords
- microgravity, ground reaction force, bone loss, neutral axis, gait, strain prediction, spaceflight
- MeSH terms
- Aged, Biomechanical Phenomena, Gait, Humans, Middle Aged, Models, Biological, Tibia, Exercise, Walking, Weightlessness Simulation, Weightlessness Countermeasures, In Vitro Techniques
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