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High-performance liquid chromatography at elevated temperatures: examination of conditions for the rapid separation of large molecules
Open accessAbstract
Liquid chromatography of large molecules at temperatures between 25 and 200°C is theoretically examined for different operating conditions including the use of micropellicular sorbents. Liquid chromatography at high temperatures is found to be beneficial in terms of both speed and efficiency and compares favorably with supercritical fluid chromatography. In order to illustrate how the decomposition of an eluite at higher temperature might affect chromatographic efficiency, the influence of temperature on a first order irreversible on-column reaction is studied. Due to the high speed of separation afforded at elevated temperatures, the deleterious effects of accelerated on-column reactions are found to be largely mitigated. Practical aspects of operation at temperatures above the normal boiling point of the mobile phase are also discussed with respect to the requirements for column stability and appropriate instrumentation.
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Cited by
Speciation of Key Arsenic Metabolic Intermediates in Human Urine
Le, X. C., Lu, X., Ma, M., Cullen, W. R., Aposhian, H. V., & Zheng, B. (2000) · Analytical Chemistry · doi:10.1021/ac000527u · Cited by 332
Simone, P., Pierri, G., Foglia, P., Gasparrini, F., Mazzoccanti, G., Capriotti, A. L., Ursini, O., Ciogli, A., & Laganà, A. (2016) · Journal of Separation Science · doi:10.1002/jssc.201500844 · Cited by 24
Metadata
- Authors
- D. Antia, F., & Horváth, C.
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 1988
- Volume
- 435
- Pages
- 1-15
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W1965577498
- Cited by
- 254
- References
- 0
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- D. Antia, F., & Horváth, C. (1988). High-performance liquid chromatography at elevated temperatures: examination of conditions for the rapid separation of large molecules. Journal of Chromatography A. https://doi.org/10.1016/s0021-9673(01)82158-0
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
