The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation and intracellular trafficking of the ABCA1 transporter
Open accessAbstract
The discovery of the role of the ATP-binding cassette transporter A1 (ABCA1) in mediating apolipoprotein A-I-mediated efflux has led to a dramatic increase in our knowledge of the molecular mechanisms involved in cholesterol efflux and cellular metabolism. In this review, we discuss several aspects of ABCA1 regulation including i) transcriptional regulation, ii) substrate specificity and availability, iii) accessory proteins, iv) acceptor specificity and availability, and v) protein trafficking. The majority of studies of ABCA1 regulation to date have focused on the identification of promoter elements that determine ABCA1 gene transcription. Here we also review the potential functional role of ABCA1 in reverse cholesterol transport. Given the key role that ABCA1 plays in cholesterol homeostasis, it is likely that there are multiple mechanisms for controlling the overall transporter activity of ABCA1.
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Chinetti, G., Lestavel, S., Bocher, V., Remaley, A. T., Neve, B., Torra, I. P., Teissier, E., Minnich, A., Jaye, M., Duverger, N., et al. (2001) · Nature Medicine · doi:10.1038/83348 · Cited by 1,170
Self-citation
Cited by
The human ATP-binding cassette (ABC) transporter superfamily
Dean, M., Hamon, Y., & Chimini, G. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31588-1 · Cited by 1,302
Oram, J. F., & Heinecke, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00005.2005 · Cited by 521
ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease
Oram, J. F., & Vaughan, A. M. (2006) · Circulation Research · doi:10.1161/01.res.0000250171.54048.5c · Cited by 411
Ito, A., Hong, C., Rong, X., Zhu, X., Tarling, E. J., Hedde, P. N., Gratton, E., Parks, J., & Tontonoz, P. (2015) · eLife · doi:10.7554/elife.08009 · Cited by 281
“Prior work has shown that LXR-dependent induction of Abca1 contributes to the maintenance of sterol homeostasis by promoting the efflux of cellular cholesterol to extracellular acceptors such as ApoA-I and ApoE (Santamarina-Fojo et al., 2001; Oram, 2003).”
BackgroundHamilton, J. A. (2003) · Current Opinion in Lipidology · doi:10.1097/00041433-200306000-00006 · Cited by 184
Metadata
- Authors
- Santamarina-Fojo, S., Remaley, A. T., Neufeld, E. B., & Brewer, H. B.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 42
- Issue
- 9
- Pages
- 1339-1345
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2189600589
- Cited by
- 158
- References
- 1
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Santamarina-Fojo, S., Remaley, A. T., Neufeld, E. B., & Brewer, H. B. (2001). Regulation and intracellular trafficking of the ABCA1 transporter. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)30266-2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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