The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase
Open accessAbstract
The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and omega/omega-1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade. The characterization of the potent biological activities associated with several of the cytochrome P450-derived eicosanoids suggested new and important functional roles for these enzymes in cellular, organ, and body physiology, including the control of vascular reactivity and systemic blood pressures. Past and current advances in cytochrome P450 biochemistry and molecular biology facilitate the characterization of cytochrome P450 isoforms responsible for tissue/organ specific arachidonic acid epoxidation and omega/omega-1 hydroxylation, and thus, the analysis of cDNA and/or gene specific functional phenotypes. The combined application of physiological, biochemical, molecular, and genetic approaches is beginning to provide new insights into the physiological and/or pathophysiological significance of these enzymes, their endogenous substrates, and products.
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Cites
Hashimoto, T., Fujita, T., Usuda, N., Cook, W., Qi, C., Peters, J. M., Gonzalez, F. J., Yeldandi, A. V., Rao, M. S., & Reddy, J. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.19228 · Cited by 241
Cited by
Cytochrome P450 and Vascular Homeostasis
Fleming, I. (2001) · Circulation Research · doi:10.1161/hh2101.099268 · Cited by 383
Epoxides and Soluble Epoxide Hydrolase in Cardiovascular Physiology
Imig, J. D. (2012) · Physiological Reviews · doi:10.1152/physrev.00021.2011 · Cited by 365
Jiang, J.-G., Chen, C.-L., Card, J. W., Yang, S., Chen, J.-X., Fu, X.-N., Ning, Y.-G., Xiao, X., Zeldin, D. C., & Wang, D. W. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4173 · Cited by 284
Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids
Konkel, A., & Schunck, W.-H. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2010.09.009 · Cited by 227
Schmidt, K., Hughes, C., Chudek, J. A., Goodyear, S. R., Aspden, R. M., Talbot, R., Gundersen, T. E., Blomhoff, R., Henderson, C., Wolf, C. R., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01638-08 · Cited by 61
Metadata
- Authors
- Capdevila, J. H., Falck, J. R., & Harris, R. C.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 41
- Issue
- 2
- Pages
- 163-181
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2182635476
- Cited by
- 552
- References
- 1
- FWCI
- 11.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase. https://app.cochat.ai/papers/10.1016/s0022-2275(20)32049-6
- The paper
- Capdevila, J. H., Falck, J. R., & Harris, R. C. (2000). Cytochrome P450 and arachidonic acid bioactivation: molecular and functional properties of the arachidonate monooxygenase. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)32049-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
