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An improved and simplified radioisotopic assay for the determination of free and esterified carnitine
Open accessAbstract
The radioisotopic assay for carnitine first described by Cederblad and Lindstedt (Clin. Chim. Acta. 37:235-543, 1972) and modified by Bohmer et al (Clin. Chim. Acta. 57:55-61, 1974) has been improved and simplified. As a result, the assay yields a linear response over a wide range of carnitine concentrations without the need for excessive amounts of labeled acetyl-CoA. In addition, it will measure very small quantities of carnitine even in the presence of excess acylcarnitine. The method allows rapid determination of free and esterified carnitine in small volumes of plasma (50 mul is sufficient) without the need for prior deproteinization of the samples.
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Citations
Cited by
Carnitine and Acylcarnitines: Pharmacokinetic, Pharmacological and Clinical Aspects
Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.1007/bf03261931 · Cited by 493
Liedtke, A. J., Nellis, S., & Neely, J. R. (1978) · Circulation Research · doi:10.1161/01.res.43.4.652 · Cited by 288
Genetic risk factors associated with lipid-lowering drug-induced myopathies
Vladutiu, G. D., Simmons, Z., Isackson, P. J., Tarnopolsky, M., Peltier, W. L., Barboi, A. C., Sripathi, N., Wortmann, R. L., & Phillips, P. S. (2006) · Muscle & Nerve · doi:10.1002/mus.20567 · Cited by 253
Bonnefont, J. P., Specola, N. B., Vassault, A., Lombes, A., Ogier, H., de Klerk, J. B. C., Munnich, A., Coude, M., Paturneau-Jouas, M., & Saudubray, J. M. (1990) · European Journal of Pediatrics · doi:10.1007/bf02072043 · Cited by 168
Winter, B., Fiskum, G., & Gallo, L. (1995) · British Journal of Cancer · doi:10.1038/bjc.1995.482 · Cited by 88
Metadata
- Authors
- McGarry, J. D., & Foster, D. W.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1976-05
- Volume
- 17
- Issue
- 3
- Pages
- 277-281
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2307853259
- Cited by
- 523
- References
- 0
- FWCI
- 10.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McGarry, J. D., & Foster, D. W. (1976). An improved and simplified radioisotopic assay for the determination of free and esterified carnitine. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)36985-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
