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Ceramides of pig epidermis: structure determination
Open accessAbstract
Seven distinguishable groups of ceramides have been isolated from pig epidermis and identified. In order of increasing polarity there are: 1, N-(omega-acyloxy)acylsphingosines (7.7%); 2, N-acylsphingosines (42.4%); 3, N-acylphytosphingosines (10.2%); 4, N-(alpha-hydroxy)acylsphingosines (12,1%); 5, N-(alpha-hydroxy)acylsphingosines (10.5%); 6a, N-[omega-(alpha-hydroxy)acyloxy]acylsphingosines (1.7%); 6b, N-(alpha-hydroxy)-acylphytosphingosines (15.5%). In ceramide 5, the alpha-hydroxyacid moieties are predominantly C16, whereas in ceramides 4, 6a, and 6b, the alpha-hydroxyacids are mainly C24-C28. The omega-hydroxyacids in ceramides 1 and 6a are mainly C30-C32. In ceramide 1, the fatty acids esterified to the omega-hydroxyl group contain a high proportion of linoleic acid (74.5%). These ceramides apparently form a large proportion of the intercellular lipid lamellae in the epidermal stratum corneum, which are thought to constitute the barrier to water loss.
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Cited by
Fatty acid elongases in mammals: their regulation and roles in metabolism
JAKOBSSON, A., WESTERBERG, R., & JACOBSSON, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.01.004 · Cited by 936
Structural Investigations of Human Stratum Corneum by Small-Angle X-Ray Scattering
Bouwstra, J. A., Gooris, G. S., van der Spek, J. A., & Bras, W. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12492217 · Cited by 567
Ceramide composition of the psoriatic scale
Motta, S., Monti, M., Sesana, S., Caputo, R., Carelli, S., & Ghidoni, R. (1993) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(93)90135-n · Cited by 435
Stratum corneum lipids: the effect of ageing and the seasons
Rogers, J., Harding, C., Mayo, A., Banks, J., & Rawlings, A. (1996) · Archives of Dermatological Research · doi:10.1007/bf02505294 · Cited by 415
Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?
Mollanazar, N. K., Smith, P. K., & Yosipovitch, G. (2016) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-015-8488-5 · Cited by 353
Metadata
- Authors
- Wertz, P. W., & Downing, D. T.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1983-06
- Volume
- 24
- Issue
- 6
- Pages
- 759-765
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2185658394
- Cited by
- 355
- References
- 0
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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