Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat
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Rates of sterol synthesis were measured in 17 tissues of the rat, and the responsiveness of these rates to cholesterol feeding and to fasting was determined. The liver and gastrointestinal tract together account for 90% of synthetic activity of the whole body. After the rats had been fed cholesterol or fasted, liver synthesis was markedly decreased, whereas synthetic rates in all other organs tested were essentially unaffected (this conclusion applies to synthesis of cholesterol and of five other digitonin-precipitable tissue sterols). Consequently, the highest rate of cholesterogenesis in the cholesterol-fed or fasted rat is found in the gastrointestinal tract.
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Digitonin precipitates not only cholesterol but also several intermediates in the biosynthetic pathway, including desmosterol, lathosterol and lanosterol.
“It should be emphasized here that digitonin precipitates not only cholesterol but also several of the intermediates in the biosynthetic pathway including desmosterol, lathosterol and lanosterol (Dietschy and Siperstein, 1967).”
From Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis (2017) · cites this paper as Dietschy and Siperstein, 1967
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References 19 · Cited by 296
- Authors
- Dietschy, J. M., & Siperstein, M. D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1967-03
- Volume
- 8
- Issue
- 2
- Pages
- 97-104
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2206929854
- Cited by
- 296
- References
- 19
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 44.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Lipid Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- sterol biosynthesis, cholesterol feeding, fasting, cholesterogenesis, liver, gastrointestinal tract, rats
- MeSH terms
- Animals, Cholesterol, Dietary, Digestive System, Fasting, Kinetics, Liver, Male, Sterols, Tissue Distribution, Rats, Sprague-Dawley, Rats
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