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Damage to proteins by peroxidized lipids
Open accessAbstract
The purpose of this research was to determine the mechanism of damage to protein by the free radical intermediates formed during the peroxidation of lipids. The reaction system consisted of linolenic acid, cytochrome c, and oxygen. The addition reaction of peroxidizing linolenic acid with cytochrome c was measured using linolenic acid-C14. There was considerable damage to cytochrome c as measured by its decreased solubility. Paper chromatographic studies of the amino acids of the linolenic peroxy–cytochrome c product showed losses of amino acids that are labile to oxidation. Linkages between linolenic acid and cytochrome c were identified as either peroxy or ether by infrared spectra. Hydrolysis revealed that 70% of the linolenic acid was bound to cytochrome c through peroxy bonds, and the rest through ether or possibly carbon-to-carbon bonds. Measurements of thiobarbituric acid value and peroxide number substantiated the chemical nature of peroxidative damage to cytochrome c.
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Citations
Cited by
An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone‐exposed rats
Chow, C. K., & Tappel, A. L. (1972) · Lipids · doi:10.1007/bf02533017 · Cited by 344
Self-citationOxene Donors Yield Low‐Level Chemiluminescence with Microsomes and Isolated Cytochrome P‐450
CADENAS, E., SIES, H., GRAF, H., & ULLRICH, V. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07125.x · Cited by 44
Metadata
- Authors
- Desai, I. D., & Tappel, A. L.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 1963-04
- Volume
- 4
- Issue
- 2
- Pages
- 204-207
- ISSN
- 0022-2275 (ISSN-L)
- OpenAlex
- W2100570011
- Cited by
- 171
- References
- 0
- FWCI
- 17.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Desai, I. D., & Tappel, A. L. (1963). Damage to proteins by peroxidized lipids. Journal of Lipid Research. https://doi.org/10.1016/s0022-2275(20)40348-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
