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Cited by 132Pediatric Urology and Nephrology StudiesHormonal Regulation and HypertensionIon Transport and Channel Regulation

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Transient pseudohypoaldosteronism secondary to obstructive uropathy in infancy

Rodríguez-Soriano, Juan, Vallo, Alfredo, Oliveros, Roberto, Castillo, Gonzalo·1983·The Journal of Pediatrics
DOI 10.1016/s0022-3476(83)80406-5
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Abstract

A syndrome of renal tubular resistance to aldosterone has been identified in infants with obstructive uropathy and urinary tract infection. Six infants (ages 9 days to 7 months) were seen with fever, vomiting, polyuria, dehydration, or failure to thrive. Urine cultures were positive for Escherichia coli. Radiologic studies demonstrated bilateral ureterohydronephrosis (four patients), left ureteral duplication with upper pole hydronephrosis (one), and left vesicoureteral reflux (one). The infants had hyponatremia, hyperkalemia, and metabolic acidosis. Plasma aldosterone concentration was markedly elevated, and plasma renin activity was similar to or higher than that reported in normal infants of comparable age. Fractional excretion of potassium was not significantly different from control values, both in absolute terms or when related to glomerular filtration rate, but fractional sodium excretion was significantly increased. The UK/UNa ratio was significantly lower in the patients. After medical or surgical therapy (when appropriate), all blood and urine determinations returned to normal, except for UK/UNa values, which although higher, remained significantly diminished. Our data indicate that a hyperkalemic salt-losing state can arise in infants with obstructive uropathy and urinary tract infection as a consequence of tubular unresponsiveness to aldosterone, and that the clinician should rule out such cause before establishing the diagnosis of primary pseudohypoaldosteronism.

Overview

Integrity signals

Registry

Crossref · 10.1016/s0022-3476(83)80406-5

Cites

30 of 30 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 4

  1. Yarger, 1982, Effect of urinary obstruction on renal tubular function, Semin Nephrol, 2, 17
  2. Moll, 1982, Apparent pseudohypoaldosteronism with unilateral obstructive uropathy in an infant, Clin Res, 30, 799A
  3. Unal, 1975, Hyponatrémie avec fuite urinaire de sodium chez le nouveauné et le nourrisson, Pediatrie, 30, 729
  4. Morrison, 1982, Alterations in intrarenal hormones in urinary tract obstruction, Semin Nephrol, 2, 40

Cited by

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Metadata

Authors
Rodríguez-Soriano, J., Vallo, A., Oliveros, R., & Castillo, G.
ORCID
Castillo, Gonzalo
Venue
The Journal of Pediatrics
Publisher
Elsevier BV
Published
1983-09
Volume
103
Issue
3
Pages
375-380
ISSN
0022-3476 (ISSN-L)
DOI
10.1016/s0022-3476(83)80406-5
OpenAlex
W2074548377
Cited by
132
References
30
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 2 · 2015: 7 · 2014: 1 · 2013: 2 · 2012: 6
FWCI
4.65
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Journal of Pediatrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Urology and Nephrology Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
urinary tract obstruction, infants, urinary tract infection, aldosterone resistance, hyponatremia, hyperkalemia, metabolic acidosis, fractional excretion of sodium, hydroureteronephrosis, vesicoureteral reflux, ureteral duplication, plasma aldosterone, plasma renin activity
MeSH terms
Aldosterone, Creatinine, Female, Glomerular Filtration Rate, Humans, Infant, Infant, Newborn, Kidney Tubules, Male, Potassium, Renin, Sodium, Ureteral Obstruction, Urinary Tract Infections

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.