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THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES
Abstract
Methods are described for the determination of acetanilide and its metabolites. The procedure for acetanilide permits estimation of as little as 4 micrograms of the compound, that for aniline as little as 0.25 micrograms, for N-acetyl p-aminophenol and total conjugated p-aminophenol as little as 10 micrograms. A comparison of the solubility characteristics of the authentic compounds and the apparent compounds extracted from the plasma and urine of subjects receiving acetanilide, indicates that the methods have a high degree of specificity.
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Citations
Cited by
ASCORBIC ACID IN AROMATIC HYDROXYLATION
Udenfriend, S., Clark, C. T., Axelrod, J., & Brodie, B. B. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65598-x · Cited by 677
Self-citationParacetamol Overdosage Pharmacological Considerations and Clinical Management
Prescott, L. F. (1983) · Drugs · doi:10.2165/00003495-198325030-00002 · Cited by 425
Mechanism of Action of Acetaminophen: Is There a Cyclooxygenase 3?
Botting, R. M. (2000) · Clinical Infectious Diseases · doi:10.1086/317520 · Cited by 350
Paracetamol – An old drug with new mechanisms of action
Przybyła, G. W., Szychowski, K. A., & Gmiński, J. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13392 · Cited by 190
Can paracetamol (acetaminophen) be administered to patients with liver impairment?
Hayward, K. L., Powell, E. E., Irvine, K. M., & Martin, J. H. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12802 · Cited by 104
Metadata
- Authors
- Brodie, B. B., & Axelrod, J.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1948-09
- Volume
- 94
- Issue
- 1
- Pages
- 22-28
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1920770313
- Cited by
- 320
- References
- 0
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES. https://app.cochat.ai/papers/10.1016/s0022-3565(25)03461-5
- The paper
- Brodie, B. B., & Axelrod, J. (1948). THE ESTIMATION OF ACETANILIDE AND ITS METABOLIC PRODUCTS, ANILINE, N-ACETYL p-AMINOPHENOL AND p-AMINOPHENOL (FREE AND TOTAL CONJUGATED) IN BIOLOGICAL FLUIDS AND TISSUES. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)03461-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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