Cited by 271Nitric Oxide and Endothelin EffectsHeart Rate Variability and Autonomic ControlBlood Pressure and Hypertension Studies

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A central nervous system action of nitric oxide in blood pressure regulation

Togashi, H, Sakuma, I, Yoshioka, M, Kobayashi, T, Yasuda, H, Kitabatake, A, Saito, H, Gross, S S, Levi, R·1992·The Journal of Pharmacology and Experimental Therapeutics

DOI 10.1016/s0022-3565(25)10757-x

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Abstract

We had reported that the systemic administration of N omega-methyl-L-arginine (L-NMA), a specific inhibitor of nitric oxide (NO) synthesis from L-arginine (ARG), raises arterial blood pressure (BP) while paradoxically enhancing central sympathetic outflow. Cervical spinal cord transection abolishes the increase in sympathetic outflow and attenuates the pressor effect of L-NMA. Thus, in addition to lowering BP by direct vasorelaxation, NO may also act in the central nervous system to reduce vascular sympathetic tone. To test this hypothesis we have injected L-NMA directly into the central nervous system in anesthetized rats. Intracisternally (i.c.), L-NMA elicited a small pressor response accompanied by a marked increase in sympathetic renal nerve activity (RNA). In contrast, the inactive stereoisomer N omega-methyl-D-arginine had neither pressor nor neural effects. The increases in RNA and BP elicited by i.c. L-NMA were abolished by spinal cord transection at C1 to C2 and by the i.v. administration of ARG. When administered i.c., ARG also abolished the increase in RNA elicited by i.v. L-NMA and significantly attenuated the pressor response. Thus, our findings indicate that L-NMA acts centrally by an ARG-reversible mechanism in the anesthetized rat to stimulate sympathetic nerve activity. Inasmuch as centrally synthesized NO has been postulated to play a second messenger and/or neurotransmitter role, our findings suggest that one such function would be the central regulation of sympathetic outflow and hence, BP.

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“, 1992), while Togashi and his colleagues, ehcited elevations in arterial pressure and renal sympathetic nerve activity with intra-cisternal injections of LNMMA (Togashi et al., 1992).”
Background

Authors: Togashi, H., Sakuma, I., Yoshioka, M., Kobayashi, T., Yasuda, H., Kitabatake, A., Saito, H., Gross, S. S., & Levi, R.
Affiliations: Hokkaido University (JP)
ORCID: Sakuma, I
Kobayashi, T
Saito, H
Levi, R
Venue: The Journal of Pharmacology and Experimental Therapeutics
Publisher: Elsevier BV
Published: 1992-07
Volume: 262
Issue: 1
Pages: 343-347
ISSN: 0022-3565 (ISSN-L)
DOI: 10.1016/s0022-3565(25)10757-x
OpenAlex: W1953075977
Cited by: 270
References: 0
Citations by year: 2022: 3 · 2021: 6 · 2020: 2 · 2019: 4 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 10.61
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed
Funders: National Heart, Lung, and Blood Institute (P01HL046403, HL-46403, HL-34215, R01HL034215)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: nitric oxide, blood pressure regulation, L-arginine, central nervous system, sympathetic activity, renal sympathetic nerve activity, pressor response, spinal cord transection, intracisternal administration, neurotransmitter function, vasorelaxation
MeSH terms: Animals, Arginine, Blood Pressure, Central Nervous System, Heart Rate, Male, Nitric Oxide, Pressoreceptors, Rats, Inbred Strains, RNA, omega-N-Methylarginine, Rats

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A central nervous system action of nitric oxide in blood pressure regulation

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