The DOI matches its Crossref record.
ABSORPTION OF DRUGS FROM THE RAT SMALL INTESTINE
Abstract
The relative rates of absorption of a large number of drugs have been measured by perfusing solutions of drugs through the entire small intestine of the anesthetized rat. A single perfusion of the small intestine differentiated very rapid absorption from less rapid absorption. A continuous recirculation of the drug solution through the intestine separated less rapid absorption from very slow absorption. The degree of ionization of an organic electrolyte in solution appears to be one of the most important factors determining its absorption from the rat small intestine. Acidic drugs were rapidly absorbed if their pK a 9s were greater than 3. Basic drugs were rapidly absorbed if their pK a 9s were less than 8. The stronger acids and bases were relatively slowly absorbed and the absorption of very strong acids and bases was imperceptible. Absorption of drugs from the rat small intestine can be best explained by assuming simple diffusion of unionized drug across a barrier which may be lipoidal in nature.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Physicochemical Profiling (Solubility, Permeability and Charge State)
Avdeef, A. (2001) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026013395100 · Cited by 587
Pappenheimer, J. R., & Reiss, K. Z. (1987) · The Journal of Membrane Biology · doi:10.1007/bf02209145 · Cited by 522
50 years of oral lipid-based formulations: provenance, progress and future perspectives
Feeney, O. M., Crum, M. F., McEvoy, C. L., Trevaskis, N. L., Williams, H. D., Pouton, C. W., Charman, W. N., Bergström, C. A. S., & Porter, C. J. H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.007 · Cited by 426
The significance of acid/base properties in drug discovery
Manallack, D. T., Prankerd, R. J., Yuriev, E., Oprea, T. I., & Chalmers, D. K. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35348b · Cited by 329
H + ‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine
Thwaites, D. T., & Anderson, C. M. H. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.029959 · Cited by 188
Metadata
- Authors
- Schanker, L. S., Tocco, D. J., Brodie, B. B., & Hogben, C. A. M.
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1958-05
- Volume
- 123
- Issue
- 1
- Pages
- 81-88
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W2224010948
- Cited by
- 371
- References
- 0
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: ABSORPTION OF DRUGS FROM THE RAT SMALL INTESTINE. https://app.cochat.ai/papers/10.1016/s0022-3565(25)12018-1
- The paper
- Schanker, L. S., Tocco, D. J., Brodie, B. B., & Hogben, C. A. M. (1958). ABSORPTION OF DRUGS FROM THE RAT SMALL INTESTINE. The Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1016/s0022-3565(25)12018-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
