Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
Abstract
Pharmacological studies have provided important information relevant to the behavioral role of central nervous system (CNS) dopamine (DA) as well as the existence of multiple DA receptors in the CNS. In the present experiment, the i.v. self-administration of several compounds that are direct DA receptor agonists was evaluated in rhesus monkeys. Apomorphine, piribedil, propylbutyldopamine and bromocriptine were self-administered by at least half of the animals tested, whereas SKF 38393 failed to maintain self-administration. Each of the compounds that was self-administered is an agonist at the DA2 receptor that has been demonstrated in the periphery, whereas SKF 38393 is principally a DA1 agonist. The results suggest that a DA receptor that is similar to the DA2 receptor is involved in this behavioral effect. In addition, the results are consistent with the hypothesis that CNS DA is involved in the reinforcing properties of psychomotor stimulants.
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Direct DA receptor agonists can mimic the effects of substances of abuse and are self-administered both systemically and locally into the NAc in rats and monkeys.
“Direct DA receptor agonists can mimic the effects of substances of abuse, and these agonists are self-administered both systemically and locally into the NAc in rats and monkeys [131-133].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [132]
Rodents will not self-administer selective D1R agonists, which by themselves induce conditioned place aversion.
“Nonetheless, rodents will not self-administer selective D1R agonists, which, by themselves, induce conditioned place aversion (Woolverton et al 1984; Hoffman and Beninger 1988).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Woolverton et al 1984
D2R is necessary for reward and incentive learning and maintenance of reward- and incentive-related responding, and rats will self-administer drugs that activate these receptors.
“D2R is also necessary for reward and incentive learning, as well as maintenance of reward- and incentive-related responding, and rats will readily self-administer drugs that activate these receptors (Woolverton et al 1984; Sanger 1986; Woolverton 1986; Hoffman et al 1988; for an early review of the roles of D1R and D2R in reward and reinforcement, see Beninger et al 1989).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Woolverton et al 1984
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Cited by 204
- Authors
- Woolverton, W. L., Goldberg, L. I., & Ginos, J. Z.
- ORCID
- Goldberg, L I
- Venue
- The Journal of Pharmacology and Experimental Therapeutics
- Publisher
- Elsevier BV
- Published
- 1984-09
- Volume
- 230
- Issue
- 3
- Pages
- 678-683
- ISSN
- 0022-3565 (ISSN-L)
- OpenAlex
- W1916785887
- Cited by
- 204
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 9
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pharmacology and Experimental Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine agonists, intravenous self-administration, rhesus monkeys, apomorphine, piribedil, bromocriptine, SKF 38393, dopamine D2 receptor, dopamine D1 receptor, psychostimulants, reinforcing properties
- MeSH terms
- Animals, Apomorphine, Benzazepines, Bromocriptine, Cocaine, Dextroamphetamine, Dopamine, Female, Macaca mulatta, Male, Motor Activity, Piribedil, Receptors, Dopamine, Self Administration, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
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